脑钠肽联合胱抑素C检测在慢性心力衰竭患者中的应用

Application of combined detection of brain natriuretic peptide and cystatin C in the patients with chronic heart failure CHEN Tu WANG Benren LI Yanyan

目的探讨脑钠肽联合胱抑素C检测在慢性心力衰竭患者中的应用效果及价值。方法随机抽取我院在2012年5月-2013年5月期间收治的慢性心力衰竭患者63例的临床资料进行回顾性分析，将本组患者按照检测方法的不同分为三组，A组、B组和C组，每组A组例行单纯的胱抑素C检测，B组例行单纯的脑钠肽检测，C组例行脑钠肽、胱抑素C联合检测，针对三组患者的检测结果以及在慢性心力衰竭患者诊断中的应用效果进行系统评价。结果A组诊断正确率为71．4％，B组诊断正确率为66．7％，C组诊断正确率为95．2％，A组和B组的诊断结果差异不显著，不具有统计学意义（P〉O．05）；C组诊断正确率明显高于A组和B组，差异显著，具有统计学意义（P〈0．05）。结论采用脑钠肽，胱抑素c联合检测应用慢性心力衰竭患者的诊断，可以有效地提高诊断准确率，为慢性心力衰竭患者正确诊断与治疗提供科学依据，值得临床推广与应用。

Objective To investigate the application effect and value of combined detection of brain natriuretic peptide and cystatin C in the patients with chronic heart failure. Methods The clinical data of 63 cases with chronic heart failure chosen randomly in our hospital during May 2012 to May 2013 were retrospectively analyzed. The patients were divided into three groups according to different detection methods, namely group A, group B and group C. The patients in group A were detected cystatin C, that in group B were detected brain natriuretic peptide, while that in group C were detected brain natriuretic peptide and cystatin C. The detection results of patients in three groups and their application effects in the diagnosis of patients with chronic heart failure were systematically evaluated. Results The rate of correct diagnosis in group A was 71.4%, that in group B was 66.7%, and that in group C was 95.2%. The difference was not statistically significant in the rate of correct diagnosis between group A and group B（P 〈0.05）; The rate of correct diagnosis in group C was significantly higher than that in group A and group B, the difference was statistically significant（P 〈 0.05）. Conclusion Combined detection of brain natriuretic peptide and cystatin C in the diagnosis of patients with chronic heart failure can effectively improve the rate of correct diagnosis, and provide scientific basis for correct diagnosis and treatment in patients with chronic heart failure, and it is worthy of clinical promotion and application.