躯体化障碍患者述情障碍与认知电位P300

Alexithymia and cognitive potential p300 in patients with somatizationdisorder

目的探讨躯体化障碍患者的述情障碍与认知功能的关系。方法 56例躯体化障碍患者和50名正常对照者进行多伦多述情障碍量表(Toronto alexithymia scale,TAS-20)和事件相关电位P300测定,分析所得结果。结果躯体化障碍组的TAS总分、F1、F2、F3因子分均高于正常对照组,差异有统计学意义(P<0.05);躯体化障碍组的TAS总分与N2、P2、P3潜伏期成正相关,与P2、P3波幅成负相关(P<0.05或P<0.01);F1与P2波幅呈负相关,与N2、P3潜伏期正相关;F2与P2、P3波幅呈负相关,与N2、P2及P3潜伏期正相关(P<0.05或P<0.01);F3与P3潜伏期成正相关,与P2、P3波幅呈负相关(P<0.05或P<0.01)。结论躯体化障碍患者存在述情障碍,且述情障碍可能影响了患者的认知功能。

Objective To explore the relationship between alexithymia and cognitive function in patients with somatization disorder（SD）. Methods 56 SD patients and 50 controllers were evaluated with Toronto alexithymia scale（TAS-20） and event related potential P300,the results were analyzed with t-test and correlation analysis. Results The total score and scores of F1,F2 and F3 of TAS-20 in somatization disorder patients were higher than those in controllers（P 〈 O.05）.The total score of TAS-20 correlated positively with the latency of N2,P2 and P3,and negatively with amplitude of P2 and P3.The score of F1 was correlation with N2,P2 and P3 positively, and amplitude of P2 and P3 negatively, thescore of F2 was positive correlation with latency of N2,P2 and P3 and negative correlation with amplitude of P2 and P3.The score of F3 was positive correlation with latency of P3 and negative correlation with amplitude of P2 and P3. Conclusion Somatization disorder patients have obvous alexithymia,and alexithymia is correlation with cognition,which provide cue for intervention of cognitive impairment.