原发性高血压并心力衰竭者血浆神经肽Y含量变化及临床意义

Change of Plasma Neuropeptide Y Level in Patients with Heart Failure Due to Primary Hypertention

采用放射免疫分析法探讨血浆神经肽 Y(NPY)含量变化在高血压合并心衰中的临床意义。结果 :原发性高血压并发心衰患者血浆 NPY含量较对照组显著升高 (P<0 .0 1) ;且左心衰组显著高于无心衰组 (P<0 .0 1) ;全心衰组高于左心衰组 (P<0 .0 5 )。提示血浆 NPY含量变化在高血压并发心衰中可能起着一定的作用。

To study the clinical significance of neuropeptide Y(NPY) in patients with heart failure due to primary hypertension, the plasma NPY levels were measured by RIA. Results:the plasma NPY levels werer much higher in patients with hypertension and heart failure due to hypertension than that in mormal subjects(P<0.01), and the levels in the cases of left heart failure(HF) were much higher than those in the cases without HF, and the levels werer higher in whole HF than those in left HF. Conclusions:the changes of plasma NPY may play an important role in the pathogenesis of hypertension complicated by heart failure.