酒精性脂肪肝患者幽门螺杆菌感染率调查

Helicobacter pylori infection in patients with alcoholic fatty liver

目的探讨酒精性脂肪肝(alcoholic fatty liver,AFL)患者幽门螺杆菌(Helicobacter pylori,Hp)感染情况。方法收集2012年5月—2013年5月在西安交通大学医学院第二附属医院体检中心体检人群为研究对象,采用上腹部B超检测其有无脂肪肝,再结合饮酒史诊断AFL,并采用血Hp抗体检测Hp感染,生化分析仪检测肝功能,用SPSS 13.0软件进行统计分析。结果①AFL组403例,Hp感染率为22.6%;对照组1867例,Hp感染率为21.6%,2组比较差异无统计学意义(P>0.05)。②轻、中、重度AFL患者Hp感染率分别为23.0%、21.1%、20.7%,3组比较差异无统计学意义(P>0.05)。③AFL患者中,Hp阳性和阴性人群的肝功能无明显差异(P均>0.05)。结论 Hp感染与AFL及肝功能无明显关系。

Objective To investigate Helicobacter pylori （Hp） infection in patients with alcoholic fatty liver （AFL）. Methods People who had physical examination at Medical Examination Center of the Second Affiliated Hospital of Medical School of Xi＇an Jiaotong University from May 2012 to May 2013 were enrolled in the study. Abdominal uhrasound scan was used and alcohol-drinking history was considered to make the diagnosis of AFL. Hp whole blood antibody test was used for diagnosis of Hp infection. An automatic biochemistry analyzer was used to detect liver function. SPSS 13.0 was used to analyze the data. Results Hp infection was found in 22.6% of the patients in AFL group （n=430）, and 21.6% in the control group （n=1867）, with no significant difference between the 2 groups （P〉0.05）. The Hp infection rates of patients with mild, moderate and severe AFL were 23.0%, 21.1% and 20.7%, respectively, and the differences among the 3 groups were not significant （P 〉0.05）. Liver function was not significantly different between ALF patients with and without Hp infection （P 〉0.05）. Conclusion Hp infection is not obviously correlated with ALF and liver function.