摘要
多种慢性肝脏疾病都与组织的无菌性炎症有关。核苷酸结合寡聚化结构域样受体家族形成的多蛋白复合物———炎症小体,作为炎症反应的核心,能被多种外源或内源性刺激激活,引起下游炎症因子分泌,诱发炎症反应,其过度激活会造成组织损伤。现已证实炎症小体在酒精性和非酒精性脂肪性肝病、肝脏缺血再灌注损伤及药物性肝损伤等疾病中起关键作用,是肝脏发生纤维化和癌变的决定因素之一。本文就炎症小体的结构、活化信号及激活通路、调节机制及其与慢性肝脏疾病关系的研究进展作一综述,以期为慢性肝脏疾病的治疗提供新的方向和靶点。
A variety of chronic liver diseases are associated with sterile inflammation of the tissues. Some nucleotide-binding oligomerization domain-like receptors form the inflammasome, a eytosolic muhiprotein complex, which is an important component of sterile inflammation. It can be activated by a large amount of exogenous or endogenous signals, thus inducing the secretion of in- flammatory cytokines and tissue inflammation, and excessive stimulation can cause tissue damage. Research studies have shown that the inflammasome plays a critical role in many chronic liver diseases, such as alcoholic or non-alcoholic fatty liver disease, is- chemia-reperfusion injury of liver and drug-induced liver injury. Inflammasome is an important determinant of liver fibrogenesis and carcinogenesis. This reviewe focuses on the structure of inflammasome, the related activation signal and pathway, regulatory mecha- nism and its association with chronic liver diseases. Further identification of its role may shed light on new approaches for the treat- ment of chronic liver diseases.
出处
《传染病信息》
2013年第5期319-322,共4页
Infectious Disease Information
基金
辽宁省科技厅科技攻关项目(2011225015)
