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MiR-302/367在体细胞向多能性干细胞重编程中的作用 被引量：1

Roles of MiR-302/367 in the Reprogramming Somatic Cells into Induced Pluripotent Stem Cells
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摘要 MicroRNA-302／367（miR-302／367）发现于2003年，是一类长度在21～22nt的miRNA簇，与多能性干细胞自我更新及多向分化有重要关系．在体细胞向多能性干细胞重编程中具有重要作用．miR-302／367簇中各miRNA具有相对保守的种子区及靶基因，主要通过抑制靶基因蛋白质的翻译，从而促进间质．上皮转化（mesenchymal-epithelial transition，MET）、抑制细胞周期、调控细胞分化相关基因及表观遗传水平等方式促进体细胞向多能性细胞重编程．本文对miR-302／367的发现、结构、miR．302／367在多能性细胞中的作用及在体细胞向多能性干细胞重编程中的作用及其机理等做一综述． MiR-302/367, found in 2003, were a class of miRNAs with a length of 21 - 22 nt, act importantly in self-renewal and muhiple differentiation potential maintaine in pluripotent stem ceils, also play an important role in somatic cell reprogramming. Each miRNA of miR-302/367 owns a relative conserve seed region, mainly through inhibiting target gene translation to promote mesenchymal-epithelial transition （MET）, inhibiting cell cycle, regulating differentiation associated genes＇ expression and epigenetic modification, finally acts well in somatic cell reprogramming. This paper reviews the discovery, structure of miR-302/367, their association with pluripotency and roles in somatic cell reprogramming and uncovers the molecular mechanism during the process.
作者 朱海鲸 唐芙蓉 华进联
机构地区 西北农林科技大学动物医学院
出处 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2013年第11期1002-1009,共8页 Chinese Journal of Biochemistry and Molecular Biology
基金 国家自然科学基金资助项目(No.31272518) 教育部博士点基金(RFDP No.20120204110030) 教育部优秀人才支持计划(No.NCET-09-0654)~~
关键词 微小核糖核酸簇302 367 体细胞重编程 微小核糖核酸簇 miR-302/367 somatic cell reprogramming miRNA
分类号 Q2 [生物学—细胞生物学]
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参考文献50

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中国生物化学与分子生物学报
2013年 第11期

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