胎儿颅脑扩散加权成像技术的初步探讨

A preliminary study of the fetal brain diffusion weighted imaging

目的:探讨未用镇静剂条件下胎儿颅脑DWI成像技术。方法:纳入60例单胎孕妇行胎儿颅脑扩散加权成像(DWI)。所有孕妇及胎儿未用镇静处理。通过改良常规DWI参数,缩短扫描时间,于呼气末屏气采集。所获得的图像经两名放射科医生独立进行评分,大于3分认为图像质量良好。采用组内相关系数进行统计学分析。结果:经过使用改良后的DWI序列,同时结合孕妇屏气配合,60例胎儿颅脑DWI均采集成功。所有胎脑DWI图像评分均大于3分,图像质量良好。两名放射科医生图像质量评分的组内相关系数为0.998(P<0.001)。结论:在不采用镇静的条件下结合孕妇屏气配合,使用改良的DWI序列对胎儿颅脑DWI成像是可行的。

Objective： To investigate fetal brain diffusion weighted imaging （DWI） without sedation for pregnant women and/or fetuses. Methods： 60 pregnant women with single birth were enrolled in this study. The fetal brain had modi-fied DWI examination without sedation. The conventional DWI were modified to reduce scanning time and the data were ac-quired during end-expiration breath-holding. Two radiologists evaluated the DWI images of fetal brain by images quality sco- ring system. More than 3 scores was considered acceptable image. Intra-class correlation coefficient （ICC） was used to calcu-late the agreement of the two radiologists. Results： All the 60 pregnant women underwent fetal brain DWI examination suc-cessfully by modifying DWI sequence combined with breath-holding cooperation. Two radiologists evaluated the images quality of all fetal brain DWI images. The scores of DWI images were more than 3 and all the images were acceptable. The ICC of images quality scores evaluated by the two radiologists was 0. 998 （P〈0. 001）. Conclusion： It is feasible to acquire good images of the fetal brain by modified DWI with pregnant women breath-holding cooperation without sedation.