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维生素D与慢性肝病相关性的研究进展 被引量：1

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摘要 维生素D是一种脂溶性维生素．作为固醇类衍生物．一定程度上起到类固醇激素的作用，包括调节钙磷代谢、维持骨稳态、免疫调节、抗炎症、抗纤维化、抗肿瘤等。肝脏在维生素D的合成、代谢以及发挥生物学效应中起重要作用。机体维生素D的状况和它的多效性使之与各种慢性肝病（Chronicliverdis—ease,v,，CLDs）的发病机制、严重程度和治疗效果相关。
作者 王婧涵 李嘉 赵新颜
机构地区 天津市第二人民医院肝病Ⅰ科 首都医科大学附属北京友谊医院肝病中心
出处 《肝脏》 2013年第10期714-717,共4页 Chinese Hepatology
关键词 维生素D 慢性肝病 相关性 脂溶性维生素 钙磷代谢 免疫调节 类固醇激素 生物学效应
分类号 R575 [医药卫生—消化系统]
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参考文献28

  • 1Kitson MT, Roberts SK. D-livering the message: The importance of vitamin D status in chronic liver disease. Hepatology, 2012, 57: 897-909.
  • 2Margheita T, Mahon BD. Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med, 2004,229: 1136-1142..
  • 3Holick MF. Vitamin D: evolutionary, physiological and health perspectives. Curr Drug Targets, 2011,12: 4-18.
  • 4Holick MF, Vitamin D Deficiency. N Eng J Med, 2007,357:266-281.
  • 5Hewison M. An update on vitamin D and human immunity. Clin Endocrinol(oxf), 2012, 76:315-325.
  • 6Do JE, Kwon SY, Park S,et al. Effects of vitamin D on expression of Toll-like receptors of monocytes from patients with Behcet's disease. Rheumatology (Oxford), 2008,47 : 840-848.
  • 7Dickie LJ, Church LD, Coulthard LR, et al. Vitamin D3 down- regulates intracellular Toll-like receptor 9 induced IL 6 production in human monocytes. Rheumatology ( Oxford), 20/0, 49 : 1466-1471.
  • 8Daniel C, Sartory NA, Zahn N, et al. Immune modulatory treat ment of trinitrobenzene sulfonic acid colitis with calcitriol is associ ated with a change of a Th1/Th17 to a Th2 and regulatory T cell profile. J Pharmacol Exp Ther, 2008, 324:23-33.
  • 9Chen S, Sims GP, Chen XX, et al. Modulatory effects of 1,25 di hydroxyvitamin D3 on human B cell differentiation. Journal of Im munology, 2007,179 : 1634-1647.
  • 10Vanoirbeek E, Krishnan A, Eelen G, et al. The anti-cancer and anti inflammatory actions of 1,25(OH)2D3. Clinical Endocrinology and Metabolism, 2011,25 : 593-604.

二级参考文献12

  • 1van Etten E,Branisteanu DD,Verstuyf A,et al.Analogs of 1,25-dihydroxyvitamin D3 as dose-reducing agents for classical immunosuppressants.Transplantation,2000,69:1932-1942.
  • 2Giarratana N,Penna G,Amuchastegui S,et al.A vitamin D analog down-regulates proinflammatory chemokine production by pancreatic islets inhibiting T cell recruitment and type 1 diabetes development.J Immunol,2004,173:2280-2287.
  • 3Cippitelli M,Fionda C,Di Bona D,et al.Negative regulation of CD95 ligand gene expression by vitamin D3 in T lymphocytes.J Immunol,2002,168:1154-1166.
  • 4An International Panel.Banff schema for grading liver allograft rejection:an international consensus document.Hepatology,1997,25:658-663.
  • 5Funaki H,Shimizu K,Harada S,et al.Essential role for nuclear factor kappa B in ischemic preconditioning for ischemia-reperfusion injury of the mouse liver.Transplantation,2002,74:551-556.
  • 6Aggarwal BB.Signalling pathways of the TNF superfamily:a doubleedged sword.Nat Rev Immunol,2003,3:745-756.
  • 7Lin L,Spoor MS,Gerth AJ,et al.Modulation of Th1 activation and inflammation by the NF-kappaB repressor Foxjl.Science,2004,303:1017-1020.
  • 8Beyaert R,Heyninck K,Van Huffel S.A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis.Biochem Pharmacol,2000,60:1143-1151.
  • 9Saitoh T,Yamamoto M,Miyagishi M,et al.A20 is a negative regulator of IFN regulatory factor 3 signaling.J Immunol,2005,174:1507-1512.
  • 10Wertz IE,O' Rourke KM,Zhou H,et al.De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappa B signalling.Nature,2004,430:694 -699.

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肝脏
2013年 第10期

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