光学相干断层成像术测量视网膜神经纤维层厚度对开角型青光眼早期诊断的意义

Clinical significance of retinal nerve fiber layer thickne ss measured by optical coherence tomogra phy in the early diagnosis of glaucoma

目的评价光学相干断层成像术(OCT)测量视网膜神经纤维层(RNFL)厚度在原发性开角型青光眼(POAG)早期诊断中的意义。方法正常对照组共120例(169眼),青光眼患者96例(132眼)并分为早期、进展期及晚期3组。采用OCT进行盘周RNFL厚度的测量。结果青光眼各期RNFL厚度均显著薄于正常对照组,其中早期RNFL厚度异常率为50%。RNFL在青光眼诊断中的敏感性和特异性分别为79.54%与80.47%。结论青光眼早期RNFL厚度已异常变薄,OCT对RNFL厚度的测量为青光眼诊断提供了一项新的指标。

ObjectiveTo evaluate the significance o f the retinal nerve fiber layer (RNFL) t hickness measured by optical coherence t omography (OCT) in the early diagnosis o f primary openangle glaucoma (POAG).Me thodsThe thickness of RNFL was quantifi ed by OCT in 120 normal controls (169 ey es) and 96 patients with POAG (132 eyes) .POAG cases were divided into early,advanced a nd late stages.The rate of abnormal RNFL thickness was determined in each stage.The sensitivity and specificity we re calculated.The relation between the RNFL thickness and visual field indi ces was assessed.ResultsThe RNFL was signi ficantly thinner in each stage of glauco ma than in normal controls.The rate of abnormal RNFL thickness in early stage of POAG was 50%,85.29%in advanced and 96.88% in late stage.The sensitivity was 79.55% an d specificity was 80.47%.RNFL thickne ss was significantly correlated to visua l field indices.ConclusionRNFL becomes thinner in early stage of glaucoma. Measuring the thickness of RNFL using OCT provides a new index for the diagnosi s of glaucoma.