期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

妊娠期肝内胆汁淤积症的研究进展 被引量：4

下载PDF
导出
摘要 妊娠期肝内胆汁淤积症(ICP)是妊娠中、晚期特发性肝脏疾病。由于血清胆汁酸升高,在临床上表现为以皮肤瘙痒和黄疸为特征,主要危害胎儿,出现胎儿窘迫、死胎、早产及其他新生儿并发症。ICP的病因和发病机制尚不明确。本文从遗传、激素和环境因素方面探讨了ICP的发病机制,通过胆汁酸对胎儿的影响,了解其对胎儿危害的机制,为临床上治疗ICP奠定基础。
作者 蔡贺 沈浣 鹿群
机构地区 北京大学人民医院生殖中心
出处 《中国妇产科临床杂志》 2013年第6期556-559,共4页 Chinese Journal of Clinical Obstetrics and Gynecology
关键词 妊娠 胆汁淤积 胆汁酸转运蛋白 肝内胆汁淤积症
分类号 R714.7 [医药卫生—妇产科学]
  • 相关文献

参考文献27

  • 1俞丽丽,肖凤莲,曾婷婷,彭珠芸,胡翠芳,余欣梅,普小芸,王全民,李力,胡章雪,郑英如.早发型妊娠肝内胆汁淤积症10例分析[J].重庆医学,2012,41(20):2090-2091. 被引量：8
  • 2Anzivino C, Odoardi MR, Meschiari E, et al. ABCB4 and ABCB11 mutations in intrahepatic cholestasis of pregnancy in an Italian population. Dig Liver Dis, 2013, 45: 226 - 232.
  • 3Bacq y, Sapey T, Brechot MC, et al. Intrahepatic chole?stasis of pregnancy: a French prospective study. Hepatolo?gy, 1997, 26: 358 - 364.
  • 4Geenes V, Williamson C. Intrahepatic cholestasis of preg?nancy. WorldJ Gastroenterol, 2009, 15: 2049 - 2066.
  • 5Lammert F, Marschall HU, Glantz A, et al. Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management,J Hepatol , 2000, 33: 1012 - 1021.
  • 6ChiangJY. Regulation of bile acid synthesis: pathways, nuckear receptors, and mechanisms.J Hepatol , 2004, 40: 539 - 551.
  • 7Folmer DE, Elferink RP, Paulusma CC. P4 XIPases -lipid flippases and their role in disease. Biochim Biophys Acta, 2009, 1791: 628 - 635.
  • 8Abu - Hayyeh S, Papacleovoulou G, Williamson C, et al. Nuclear receptors, bile acids and cholesterol homeostasis se?ries - bile acids and pregnancy. Mol Cell Endocrinol, 2013, 368: 120 - 128.
  • 9Huang L, Zhao A, LewJL, et al. Famesoid X receptor activates transcription of the phospholipid pump MDR3.J Bioi Chern, 2003, 278: 51085 - 51090.
  • 10Goodwin B,Jones SA, Price RR, et al. A regulatory cas?cade of the nuclear receptors, SHP - 1, and LRH - 1 repres?ses bile acid biosynthesis. Mol Cell, 2000, 6: 517 - 526.

二级参考文献9

共引文献7

同被引文献47

  • 1曹泽毅.中华妇产科学[M].北京:人民卫生出版社,2004.2170-2172.
  • 2谢幸,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2013:118-119.
  • 3Jurate Kondrackiene,Ulrich Beuers,Rimantas Zalinkevicius,Horst-Dietmar Tauschel,Vladas Gintautas,Limas Kupcinskas.Predictors of premature delivery in patients with intrahepatic cholestasis of pregnancy[J].World Journal of Gastroenterology,2007,13(46):6226-6230. 被引量：39
  • 4Favre N,Bourdel N,Sapin V,et al.Importance of bile acids for infrahepatic cholestasis of pregnancy[J].Gynecol Obstet Fertil,2010,38(4):293-295.
  • 5Lee R H,Kwok K M,Ingles S,et al.Pregnancy outcomes during an era of aggressive management for intrahepatic cholestasis of pregnancy[J].Am J Perinatol,2008,25(6):341-345.
  • 6Anzivino C, Odoardi MR,Meschiari E,et al. ABCB4 and ABCB11 mutations in intrahepatic cholestasis of pregnancy in an Italian poputation[J]. Dig Liver Dis, 2013,45 (3) : 226-232.
  • 7Maggiore G, Gonzales E, Sciveres M, et al. Relapsing features of bile salt export pump deficiency after liver transplantation in two patients with progressive familial intrahepatic cholestasis type2 [J]. J Hepatol, 2010,53 ( 5 ) : 981-986.
  • 8Eloranta ML,Haikli T,Hiltunen M,et al. Association of single nucleotide polymorphisms of the bile salt export pump gene with intrahepatic cholestasis of pregnancy [J]. Scand J Gastroenterol, 2003,38(6) : 648-652.
  • 9Stieger B. Role of the bile salt export pump, BESP, in acquired forms of cholestasis[J]. Drug Metab Rev, 2010,42 ( 3 ) : 437-445.
  • 10Bacq Y, Sentilhes L, Reyes HB,et al. Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy:a meta- analysis[J]. Gastroenterology, 2012,143 ( 6 ) : 1492-1501.

引证文献4

二级引证文献20

中国妇产科临床杂志
2013年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部