超敏C反应蛋白与降钙素原在细菌感染中的相关性分析及诊断价值

Correlation and diagnostic value of high sensitivity C reactive protein and procalcitonin in bacterial infection

目的：探讨超敏C反应蛋白（Hs—CRP）和降钙素原（PCT）在细菌感染中的相关性，并分析二者在细菌感染临床诊断中的应用价值。方法：随机选取2013年2～5月在我院诊治的165例细菌感染者及122例非细菌感染者作为研究对象，测定两组患者血中Hs—CRP与PCT的水平，分析两者相关性及其用于预测细菌感染的价值。结果：细菌感染组患者Hs—CRP、PCT水平及白细胞总数、中性粒细胞计数显著高于非细菌感染组（t分别为15．35、9．72、13．36、13．92，P均〈0．05）。细菌感染组患者HS—CRP与PCT之间存在相关性（r=0．826，P〈0．05）。预测细菌感染时，PCT的临界值为0．39rig／L，灵敏度、特异度分别为88．2％和77．1％；Hs—CRP的临界值为41mg／L，灵敏度、特异度分别为76．2％和71．5％；两者联合预测的灵敏度和特异度分别达到92．3％和81．5％。结论：Hs—CRP与PCT可作为细菌感染临床诊断的重要依据，两者联合检测可相互补充，具有重要的临床指导意义。

Objective. To analyze the correlation and diagnostic value of high sensitivity C reactive protein （Hs-CRP） and procalcitonin （PCT） in bacterial infection. Methods. A total of 165 cases with bac- terial infection and 122 cases with non bacterial infection from February 2013 to May 2013 were collected as observation group and control group, respectively, and the level of Hs-CRP and CRP were measured. The correlation of Hs-CRP and CRP and their diagnostic value were analyzed. Results- The level of Hs- CRP, PCT, WBC, neutrophil count in patients with bacterial infection were significantly higher than those of non bacterial infection group （t=15.35, 9.72, 13.36, 13.92, P〈0.05）. There was positive correla- tion between Hs-CRP and PCT in the group of bacterial infection （r=0. 826, P〈0.05）. The cutoff point, sensitivity and specificity to predict bacterial infection were as follow, PCT （0. 39 Mg /L, 88. 2% and 77.1%） ,CRP （41 mg/L, 76.2% and 71.5%）. The sensitivity and specificity of prediction with PCT and CRP reached 92.3% and 81.5%, respectively. Conclusion. The detection of Hs-CRP and PCT can be used as an effective basis for clinical diagnosis of bacterial infection, and their joint detection can complement each other.