血清及腹腔液LN、CA125、CA199、Lp与子宫内膜异位症的相关性分析

Correlation between serum and peritoneal fluid LN,CA125,CA199,Lp and endometriosis

目的：分析血清及腹腔液层粘连蛋白（LN）、糖类抗原125（CAl25）、糖类抗原199（cAl99）、瘦素（Lp）与子宫内膜异位症的相关性。方法：选取我院2008年1月～2011年1月收治的69例子宫内膜异位症患者为观察组，并将69例同龄检查健康妇女选为对照组，比较对照组与观察组的血清及腹腔液LN、CAl25、CAl99、Lp水平，同时比较观察组不同r—AFS分期者各指标的水平，并分析其与疾病的相关性。结果：观察组血清LN、CAl25、CAl99高于对照组，腹腔液LN、CAl25、CAl99、Lp高于对照组，且观察组中r—AFS分期较高者高于分期较低者，除血清Lp外其他指标均与子宫内膜异位症有明显的相关性，差异均有统计学意义（P均〈0．05）。结论：血清与腹腔液LN、cAl25、cAl99及腹腔液Lp与子宫内膜异位症有密切的相关性，可将其作为疾病诊断与治疗效果的重要参考指标。

Objective= To analyze the correlation between the serum and peritoneal fluid LN, CA125,CA199,Lp and endometriosis. Methods= A total of 69 patients with endometriosis in our hospital from January 2008 to January 2011 were selected as observation group, 69 healthy women with same age served as the control group. Serum and peritoneal fluid LN,CA125,CA199, Lp and endometriosis of two groups were compared,the levels of observation group with different r-AFS stage were compared too, then correlation between those indexes and disease were analyzed. Results=The serum LN,CA125 and CA199 were all higher than those of control group, peritoneal fluid LN,CA125 ,CA199 and Lp were all higher than those of control group. Those indexes of observation group with higher r-AFS grade were higher than those of patients with lower r-AFS grade, except serum Lp all indexes had closed correlation with endome- triosis （all P〈0. 05）. Oonclusiorl. The correlation between the serum and peritoneal fluid LN,CA125, CA199,Lp and endometriosis is closely,and they can be important index for diagnose and treatment of dis- ease.