高度近视患者LASIK术后角膜后表面曲率变化的析因分析研究

Changes of corneal surface curvature in patients with high myopia after LASIK

目的：研究高度近视患者实施准分子激光角膜原位磨镶术（I。ASIK）手术后角膜后曲率的改变，并探讨影响角膜后表面曲率改变的因素。方法：选取2011年5月～2013年5月期间于武警总医院眼科实施I。ASIK手术治疗的高度近视患者60例，对120例眼使用orloscan1I裂隙扫描角膜地形图系统分别在术后30、60、90、180d测量角膜后表面曲率，对比后表面曲率变化，并分析其与术前眼压、承载因子之间的关系。结果：术前及术后30、60、90、180d的角膜后表面曲率半径分别为（6．53±0．24）、（6．40±0．25）、（6．44±0．23）、（6．41±0．22）、（6．38±0．21）肚m，析因实验结果表明不同术前眼压以及承载因子都会造成术后早期角膜后表面曲率不同，且术后早期角膜后表面曲率变化与术前眼压以及承载因子呈正相关的关系。结论：LAsIK术后60d内患者角膜后表面存在向前膨隆，向前膨隆在术后60d后逐渐恒定，向前膨隆与术前眼压、承载因子成正相关关系。

Objective： To investigate change of curvature of the cornea in patients with high myopia after LASIK. Methods： From May 2011 to May 2013, 60 patients with LASIK were selected. Posterior corneal surface curvature of 120 eyes was measured with Orbs can II Orbscan corneal topography system on the 30 th, 60th, 90th and 180th day, and was compared. The relationship between corneal surface cur- vature and preoperative intraocular pressure, load factor was also analyzed. Results. The preoperative cor- neal surface curvature radius was （6.53±0.24） μm; postoperative 30d posterior corneal surface curvature radius （6.40 ±0.25） μm, （6.44±0.23） μm, （6.41±0.22）μ~m and （6. 38±0.21） μm on the 30th, 60th, 90th and 180th day, respectively. Factorial experiment results showed that different preoperative in- traoeular pressure and load factor could cause different surface curvature of early corneal. Surface curva- ture corneal had positive correlation with and preoperative intraocular pressure and load factor. Conclusion： Posterior corneal surface bulges forward 60d after LASIK. It was stabilized gradually 60 d after operation. This forward bulging has positive correlation with preoperative intraocular pressure and load factor. Key- words ：