阿托伐他汀降低心肌梗死患者心血管风险的效果观察

Effect of atorvastatin on cardiovascular risk in patients with myocardial infarction

目的:探讨阿托伐他汀降低心肌梗死患者心血管风险的临床疗效。方法:回顾性分析我院收治的92例心肌梗死患者的临床资料,根据治疗方法不同分为观察组和对照组,各46例,对照组患者给予辛伐他汀治疗,观察组患者给予阿托伐他汀治疗,比较两组患者的心血管发生事件以及治疗前后的甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)。结果:观察组、对照组总心血管发生率分别为13.04%、21.74%,差异有统计学意义(P<0.05);治疗前两组TG、TC、HDL-C水平差异无统计学意义(P>0.05),治疗后观察组TG、TC均显著低于对照组,HDL-C显著高于对照组,差异有统计学意义(P<0.05)。结论:阿托伐他汀能显著降低血清中TG、TC水平,升高HDL-C水平,对降低心肌梗死患者心血管事件效果显著。

Objective： To investigate the effect of atorvastatin on cardiovascular risk in patients with myocardial infarction. Methods： Clinical data of 92 cases of myocardial infarction admitted in our hos- pital was retrospectively analyzed. They were divided into according to treatment group and control group of 46 cases according to different treatment, patients in control group were treated with simvastatin while patients in treatment group were treated with atorvastatin statin. The incidence of cardiovascular events, triglycerides （TG）, total cholesterol （TC）, and high density fatty acids （HDL-C） were compared between two groups and between before and after treatment. Flesults： The incidence of cardiovascular diseases in treatment group was 13. 04%while it was 21.74% in the control group, with significant difference be- tween the two groups （P〈0.05） ; Before treatment there was no significant difference in TO, TC, HDL- C between two groups; after treatment patients had significantly lower level of TG, TC and significantly higher HDL-C in treatment group than that of control group（P〈0.05）. Oonclusions. Atorvastatin can significantly decrease serum TG, TC levels and increase HDL-C levels, and can reduce cardiovascular e- vents incidence in patients with myocardial infarction effect.