ACEI类药物防治2型糖尿病早期肾病的研究

Study of ACEI medications in the prevention and treatment of early diabetic nephropathy of typeⅡ

目的:探讨ACEI类药物控制2型糖尿病早期肾病患者的效果。方法:符合1999年美国ADA诊断标准诊断为2型糖尿病早期肾病者,予ACEI类药物口服,使血压控制≤130/80mmHg,并测定血尿β2微球蛋白、24h尿微量白蛋白、空腹及餐后2h血糖、HbA1c。结果:ACEI类药物可使2型糖尿病早期肾病患者血压控制≤130/80mmHg,对肾脏的影响最小,可保护肾脏功能,减少尿蛋白的排泄,延缓糖尿病患者早期肾病的发生发展。结论:ACEI类药物对2型糖尿病早期肾病有较好的防治效果。

Objective： To investigate the prevention and control of the early diabetic nephropathy of type Ⅱ by using ACEI medications. Methods： Patients confirmed with early diabetic nephropathy of type Ⅱwith ADA diagnostic criteria were given oral ACEI medications to control the blood pressure lower than 130/80 mmHg. Hematuria β2 microglobulin, 24 hours＇microalbuminuria, blood glucose and HbAlc of fasting and 2 hours after meal were determined. Results： The blo was controlled under 130/80 mmHg in patients with early diabetic nephropathy of type medications. It had the least effect on kidneys, and it could protect the functions of kidn od pressure Ⅱ by ACEI eys, reduce the excretion of urinary protein and delay the occurring and development of early diabetic ne thy. Conclusion： ACEI medications has satisfactory effect on preventing and treating early nephropathy of type Ⅱ .