胰腺癌组织中人粒细胞集落刺激因子-1的表达及意义

Expression and significance of human granulocyte colony stimulating factor-1 in pancreatic carcinoma tissue

目的 研究人粒细胞集落刺激因子（hGC）-1在胰腺癌组织中的表达及其与胰腺癌临床病理参数的相关性,探讨hGC-1的表达与胰腺癌发生发展的相关性.方法 采用免疫组化SP法检测31例人胰腺导管细胞癌及其对应癌旁组织标本中hGC-1的表达,并结合临床病理资料进行相关性分析.结果 胰腺癌组织中hGC-1的表达水平明显高于癌旁组织,且表达强度与TNM分期和有无淋巴结转移密切相关（P ＜0.05）；31例胰腺癌组织中hGC-1的表达水平与患者性别、年龄无明显相关（P＞0.05）.结论 hGC-1表达上调与胰腺癌的发生、发展密切相关,hGC-1可作为反映胰腺癌恶性生物学行为的1个指标.

Objective To investigate the expression of human granulocyte colony stimulating factor-1 （HGC-1） in tissue of pancreatic carcinoma,and to explore the correlation between HGC-1 expression and the development of pancreatic carcinoma.Methods The expression of HGC-1 was examined by immunohisto-chemistrical staining in 31 pancreatic carcinoma and the adjacent pancreatic tissues,and the correlation between HGC-1 expression and clinical parameters was analyzed.Results The expression of HGC-1 was significantly higher in pancreatic carcinoma tissues than in the adjacent pancreatic tissues.The expression of HGC-1 was closely correlated with TNM stage or lymph node metastasis （P ＜ 0.05）.No correlations were found between HGC-1 expression and the age or gender in 31 pancreatic carcinoma patients （P ＞ 0.05）.Conclusion Up regulation of HGC-1 expression contributes to the progression of pancreatic carcinoma,and might be a reliable indicator to reflect the biological behavior of pancreatic carcinoma.