摘要
目的 探讨低碳水化合物饮食在改善非酒精性脂肪肝(NAFLD)方面的临床效果.方法 选取2010年9月至2012年10月在武汉大学人民医院诊断为NAFLD的男性患者58例,按随机数字表法分为低碳水化合物组(L组,n=31)与中碳水化合物组(M组,n=27),其他处理相同.检测并比较两组患者的腰围、体重、血浆葡萄糖浓度、胰岛素分泌量、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)以及高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、总胆固醇(TC)、甘油三酯(TG)的变化情况.结果 L组与M组分别有2例与4例剔除.给予饮食干预后6周,L组血糖浓度和胰岛素分泌量显著低于M组[(4.3±1.4)mol/L比(5.0±0.9) mol/L,P=0.004; (6.1±1.5) U/ml比(8.9±1.4) U/ml,P=0.001],L组ALT与AST水平均显著低于M组[(30.23±3.34) U/L比(42.33±4.46) U/L,P=0.003; (31.19±4.13) U/L比(45.21±3.73) U/L,P=0.001],L组LDL和TG水平也显著低于M组[(1.13±0.22)mmol/L比(2.71±0.67) mmol/L,P =0.001;(0.99±0.74) mmol/L比(1.42±1.06) mmol/L,P=0.001].结论 低碳水化合物饮食可改善NAFLD患者的血糖、胰岛素分泌量、肝功能指标及部分脂质代谢指标.
Objective To investigate the effects of low carbohydrate diet in treating non-alcoholic fatty liver disease (NAFLD) patients.Methods 58 male NAFLD patients selected in Renmin Hospital of Wuhan University from September 2010 to October 2012 were divided with random number table into low-carbohydrate diet group (L group,n =31) and medium-carbohydrate diet group (M group,n =27).Waistline,weight,serum glucose level,insulin secretion,glutamic-pyruvic transaminase (ALT),aspartate transaminase (AST)、high-density lipoprotein (HDL),low-density lipoprotein (LDL),total cholesterol (TC),and triglyceride (TG) of the patients were measured.Results Six patients were excluded from this research,2 in L group and 4 in M group.After 6-week's dietary intervention,blood glucose level and insulin secretion were significantly lower in L group than in M group [(4.3±1.4) mol/Lvs.(5.0±0.9) mol/L,P=0.004; (6.1 ±1.5) U/mlvs.(8.9 ± 1.4) U/ml,P =0.001].The levels of ALT and AST in L group were significantly lower than those in Mgroup[(30.23±3.34) U/Lvs.(42.33±4.46) U/L,P=0.003; (31.19±4.13) U/Lvs.(45.21±3.73) U/L,P =0.001].The levels of LDL and TG in L group were also significantly lower than those in M group [(1.13±0.22) mmol/Lvs.(2.71±0.67) mmol/L,P=0.001; (0.99±0.74) mmol/Lvs.(1.42±1.06) mmol/L,P =0.001].Conclusion In NAFLD patients,low-carbohydrate diet can improve blood glucose level,insulin secretion,liver function,and lipid metabolism disorders.
出处
《中华临床营养杂志》
CAS
CSCD
2013年第5期287-291,共5页
Chinese Journal of Clinical Nutrition