期刊文献+

小肽的吸收转运机制及生理学作用 被引量:3

Absorption and transport mechanism of small peptides and their physiological functions
原文传递
导出
摘要 小肽是蛋白质在胃肠道消化时的终产物中的主要组分之一,在蛋白质营养中具有重要作用.目前研究表明小肽可直接被肠道吸收进入循环系统,这也是体内蛋白质吸收的主要形式,但其转运体系与氨基酸的转运体系相互独立.本文就小肽的吸收转运体系、其用于肠内营养的优点及一些具有重要生理意义的小肽一一进行阐述. Small peptides is one of the main components in the final product of protein digestion in the gastrointestinal tract,which plays an important role in protein nutrition.Present studies show that small peptides in the intestine can be absorbed directly into the circulation,which is also the main form of protein absorption in vivo.However,the transporter system of small peptides is independent from that of amino acids.This paper elaborates on the absorption and transport system of small peptides,their advantages in enteral nutrition,and some small peptides with critical physiological functions.
出处 《中华临床营养杂志》 CAS CSCD 2013年第5期300-304,共5页 Chinese Journal of Clinical Nutrition
基金 国家自然科学基金(30471707)
关键词 小肽 转运体系 肠内营养 生理意义 Small peptide Transport system Enteral nutrition Physiological function
  • 相关文献

参考文献33

  • 1Agar WT,Hird FJ,Sidhu GS.The active absorption of aminoacids by the intestine[J].J Physiol,1953,121 (2):255-263.
  • 2Newey H,Smyth DH.Cellular mechanisms in intestinal transfer of amino acids[J].J Physiol,1962,164:527-551.
  • 3Hara H,Funabiki R,Iwata M,et al.Portal absorption of small peptides in rats under unrestrained conditions[J].J Nutr,1984,114 (6):1122-1129.
  • 4Ganapathy ME,Leibach FH.Is intestinal peptide transport energized by a proton gradient[J]? Am J Physiol,1985,249 (2Pt 1):G153-G160.
  • 5Charrier L,Merlin D.The oligopeptide transporter hPepT1:gateway to the innate immune response[J].Lab Invest,2006,86 (6):538-546.
  • 6陈红旗,秦环龙.寡肽转运体PepT1在胃肠道中的功能表达及调控因素[J].中华临床营养杂志,2010,18(2):115-120. 被引量:2
  • 7Yang B,Smith DE.Significance of peptide transporter 1 in the intestinal permeability of valacyclovir in wild-type and PepT1 knockout mice[J].Drug Metab Dispos,2013,41 (3):608-614.
  • 8Wu SP,Smith DE.Impact of intestinal PepT1 on the kinetics and dynamics of N-formyl-methionyl-leucyl-phenylalanine,a bacterially-produced chemotactic peptide[J].Mol Pharm,2013,10 (2):677-684.
  • 9Zucchelli M,Torkvist L,Bresso F,et al.PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease[J].Inflamm Bowel Dis,2009,15 (10):1562-1569.
  • 10Kovacs-Nolan J,Zhang H,Ibuki M,et al.The PepT1-transportable soy tripeptide VPY reduces intestinal inflammation[J].Biochim Biophys Acta,2012,1820 (11):1753-1763.

二级参考文献136

共引文献187

同被引文献26

引证文献3

二级引证文献55

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部