加味附子理中汤对慢性肾脏病患者血清纤维化指标及转化生长因子β_1表达的影响

Effect of Fuzilizhong decoction on serum fibrosis markers and TGF- β_1 in patients with chronic kidney disease

目的观察加味附子理中汤对慢性肾脏病(CKD)患者血清纤维化指标及转化生长因子β1(TGF-β1)表达的影响。方法将100例CKD患者随机分为2组。对照组50例予双嘧达莫片治疗,治疗组50例在对照组治疗基础上加用加味附子理中汤,2组均治疗3个月后观察血清纤维化指标及TGF-β1含量变化。同时选取健康体检者40人作为健康组。结果 CKD患者治疗前血清透明质酸(HA)、层黏连蛋白(LN)、Ⅳ型胶原(C-Ⅳ)及Ⅲ型前胶原(PC-Ⅲ)均较健康组明显升高(P<0.05,P<0.01)。治疗组治疗后血清HA、LN、C-Ⅳ及PC-Ⅲ均较本组治疗前及对照组治疗后下降(P<0.05)。CKD患者治疗前TGF-β1含量较健康组明显升高(P<0.01)。2组治疗后TGF-β1含量均较本组治疗前下降(P<0.01),且治疗组下降更明显(P<0.05)。结论 CKD患者血清HA、LN、C-Ⅳ、PC-Ⅲ及TGF-β1含量明显下降,加味附子理中汤有抗纤维化、缓解病情的作用。

Objective To investigate the effect of Fuzilizhong decoction on serum fibrosis markers and TGF-β1 in patients with chronic kidney disease （CKD）.Methods 100 cases with CKD （stage 1-3） were randomly divided into control group （n=50）,which was treated by western medicine for 3 months and the treatment group （n=50）,which was treated by western medicine and fuzilizhongtang decoction for 3 months （1 dose per day）.The changes of serum fibrosis markers and TGF -β1 were observed .Results The contents of serum HA ,LN,C-Ⅳand PC-Ⅲin CKD patients were increased as compared with those in health group （P〈0.05,P〈0.01）.The content of serum HA,LN,C-Ⅳand PC-Ⅲin the treatment groups were decreased as compared with those before treatment in treatment group and after treatment in control group （ P〈0.05 ） .The content of TGF -β1 in CKD patients was in-creased as compared with that in health group （P〈0.01）.The content of TGF -β1 after treatment was decreased in two groups （P〈0.01）.Decrease in treatment group was obvious （P〈0.05）.Conclusion The content of serum HA,LN,C-Ⅳ,PC-Ⅲ and TGF-β1 in Chronic kidney disease patients were significantly decreased ,Fuzilizhong decoction has the effect of anti -fibrosis and improve the conditions of chronic kidney disease .