肿瘤热消融与化疗协同作用的研究进展

Advances in the synergy between tumor thermal ablation and chemotherapy

肿瘤热消融以其无创或微创、安全有效的优点逐步被应用于多种器官肿瘤的治疗,是临床常用的微创治疗手段.但治疗范围仍存在局限,且作为有效的局部治疗手段,该技术也必然需要与肿瘤系统治疗相配合.本文概述了肿瘤热疗、热消融的概念,并介绍了热消融与化疗协同作用的可能机制,包括高温改变血供改善药物分布、高温增加药物摄取提高药物浓度、化疗药物的热增敏特性、联合应用提高完全消融率、联合促进细胞的凋亡等.

Tumor thermal ablation therapy has been the common minimally invasive technique because of its excellent efficacy and safety,and has become a promising clinical minimally invasive treatment.But there are still limitations in its therapeutic range.Moreover,as an effective local treatment,the technology is bound to a cooperation with tumor system treatments.This review provides an overview of the concept of tumor thermotherapy and thermal ablation,and the possible mechanism of the synergistic effect of the thermal ablation with chemotherapy,including hyperthermia changing the blood supply to improve drug distribution,hyperthermia increasing drug intake,hyperthermia modifying the cytotoxicity of many chemotherapeutic agents,combination therapy improving the rate of complete ablation and promoting cell apoptosis.