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FOX家族基因在肿瘤形成中的作用研究进展 被引量：4

Progress on the role of FOX family genes in oncogenesis
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摘要 转录因子FOX家族基因具有重要的生物学功能,包括调控细胞增生和分化以及肿瘤形成,其表达失调后具有致癌基因和抑癌基因的功能,相关研究已越来越受到关注.本文就目前关于FOX家族基因在相关肿瘤形成中的作用研究作一综述. Fox family transcription factors have crucial biology functions,including the regulation of proliferation,differentiation and tumorigenesis.Deregulation of Fox proteins expression may act as both oncogenes and tumor suppressors,the relevant researches have been paid more and more attentions.Here,this review focuses on the roles of Fox family genes in oncogenesis from the articles published recently.
作者 丁政 樊友本
机构地区 上海交通大学附属第六人民医院普外科
出处 《国际外科学杂志》 2013年第10期684-688,共5页 International Journal of Surgery
关键词 FOX家族基因 转录因子 癌基因 抑癌基因 肿瘤 FOX family gene Transcription factors Oncogenes Antioncogene Neoplasms
分类号 R730.2 [医药卫生—肿瘤]
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参考文献38

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  • 2Hu X,Stern HM,Ge L,et al.Genetic alterations and oncogenic pathways associated with breast cancer subtypes[J].Mol Cancer Res,2009,7(4):511-522.
  • 3Nucera C,Eeckhoute J,Finn S,et al.FOXA1 is a potential oncogene in anaplastic thyroid carcinoma[J].Clin Cancer Res,2009,15(11):3680-3689.
  • 4Thorat MA,Marchio C,Morimiya A,et al.Forkhead box A1 expression in breast cancer is associated with luminal subtype and good prognosis[J].Clin Pathol,2008,61 (3):327-332.
  • 5Sizemore ST,Keri RA.The forkhead box transcription factor FOXC1 promotes breast cancer invasion by inducing matrix metalloprotease 7 (MMP7) expression[J].J Biol Chem,2012,287(29):24631-24640.
  • 6Xu ZY,Ding SM,Zhou L,et al.FOXC1 contributes to microvascular invasion in primary hepatocellular carcinoma via regulating epithelial-mesenchymal transition[J].Int J Biol Sci,2012,8(8):1130-1141.
  • 7Bloushtain-Qimron N,Yao J,Snyder EL,et al.Cell type-specific DNA methylation patterns in the human breast[J].Proc Natl Acad Sci USA,2008,105 (37):14076-14081.
  • 8Ray PS,Wang J,Qu Y,et al.FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer[J].CancerRes,2010,70(10):3870-3876.
  • 9Brune K,Hong SM,Li A,et al.Genetic and epigenetic alterations of familial pancreatic cancers[J].Cancer Epidemiol Biomar kers Prev,2008,17(12):3536-3542.
  • 10Nonaka D,Tang Y,Chiriboga L,et al.Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms[J].Mod Pathol,2008,21 (2):192-200.

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国际外科学杂志
2013年 第10期

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