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质子泵抑制剂在呼吸系统疾病和抗病毒领域的应用 被引量：2

Novel Use of H^+/K^+-ATPase Inhibitors on Respiratory Disease and Viral Infection
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摘要 质子泵抑制剂经人体吸收后主要作用于胃内H+/K+-ATP酶,抑制胃酸分泌。临床上主要应用质子泵抑制剂治疗酸相关性疾病,如胃溃疡、胃食管反流病等。相关研究报道表明,质子泵抑制剂可以用于治疗鼻息肉、哮喘、肥达氏综合征等呼吸系统疾病,且具有良好的抗病毒作用。本文针对质子泵抑制剂在呼吸系统疾病和抗病毒领域的应用进行综述。 H^＋/K^＋-ATPase inhibitors,which inhibit gastric acid secretion,are a known class of pharmaceutical agents generally used in the treatment of gastric acid-related diseases.Some relevant reports suggest that the proton pump inhibitors can be successfully utilized for the treatment of respiratory diseases such as nasal polyps,asthma,Widal syndrome,and on the other hand,exhibit good antiviral effects.Some latest applications of H＋/K＋-ATPase inhibitors are presented in this review.
作者 李浩 施芳红 王德旺 王永庆 魏继福
机构地区 江苏省人民医院药学部临床药理实验室 上海交通大学医学院附属上海儿童医学中心药剂科 上海交通大学医学院附属上海仁济医院药剂科
出处 《药学与临床研究》 2013年第5期539-543,共5页 Pharmaceutical and Clinical Research
基金 国家自然科学基金(81273593) 科技重大专项"呼吸病新药临床评价研究技术平台建设"项目(2011ZX09302-003-02) 奥赛康临床药学科研项目(201001)
关键词 质子泵抑制剂 鼻息肉 哮喘 肥达综合征 疱疹病毒 H＋/K＋-ATPase Inhibitors Nasal polyps Asthma Widal＇s syndrome Herpesvirus
分类号 R974 [医药卫生—药品] R978.7 [医药卫生—药品]
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参考文献19

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二级参考文献35

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药学与临床研究
2013年 第5期

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