虾血对兔耳瘢痕模型的防治作用

Effects of Shrimp Blood on the Hypertrophic Scar in Rabbit Ears

为探讨虾血对抑制兔耳瘢痕增生的影响,以成年新西兰大耳白兔建立兔耳增生性瘢痕模型,将增生性瘢痕块分为对照组(A组)、虾血治疗组1(B组)和虾血治疗组2(C组),以不同组瘢痕组织石蜡包埋HE染色,观察虾血治疗对瘢痕组织中成纤维细胞、胶原纤维的影响。结果表明:肉眼观察虾血治疗组的瘢痕较空白对照组有改善;光镜下见虾血治疗组成纤维细胞减少,胶原纤维含量降低且排列较规则有序,差异具有显著性(p<0.001);虾血治疗组2微血管均数较少,抑制疤痕增生效应最好(p<0.01);虾血可能具有抑制兔耳增生瘢痕的形成及瘢痕组织增生的作用。

To investigate the effects of shrimp blood on the hypertrophic scar in rabbit ears, New Zealand white rabbits were used to establish the models of hypertrophic scar in rabbits ears. After epithelialization, the models of hypertrophic scar were divided into the control group received no special treatment （group A）, shrimp blood-treated group one （group B） and the shrimp blood-treated group two （group C）. The fibroblast and collagen fibers were observed, after HE staining. Results showed thatthe hypertrophic scars in the shrimp blood-treated group are different compared with the control group under macroscopic observation. The fibroblasts and collagen fibers were decreased and in the shrimp blood-treated group under light microscope. Shrimp blood may have an inhibition effect on hyperplastic scar formation and scar tissue hyperplasia in rabbit ears model.