雌激素受体与孕激素受体在葡萄胎组织中的表达及临床意义

Expressions of ER and PR in hydatidiform mole tissues and its clinical significance

目的:探讨雌激素受体(ER)、孕激素受体(PR)在葡萄胎组织中的表达及临床意义。方法:采用免疫组织化学(SP)法,检测20例早孕正常绒毛、20例流产绒毛水肿、28例部分性葡萄胎、35例完全性葡萄胎、9例侵袭性葡萄胎组织中ER、PR的表达情况。结果:在正常绒毛、流产绒毛水肿、部分性葡萄胎、完全性葡萄胎、侵袭性葡萄胎组织中ER的阳性率为90.0%、95.0%、67.9%、65.7%、22.2%。随着滋养细胞恶性程度的增加,ER染色阳性细胞数及染色强度降低且差异有统计学意义(P<0.05);PR在正常绒毛、流产水肿绒毛、部分性葡萄胎、完全性葡萄胎、侵袭性葡萄胎组织的阳性率为5.0%、10.0%、3.6%、2.9%、0%。PR在正常绒毛、流产水肿绒毛、葡萄胎组织中表达很少,在侵袭性葡萄胎组织中无表达。PR染色阳性细胞数及染色强度与滋养细胞恶性程度无关,差异无统计学意义(P>0.05)。结论:ER可作为正常绒毛、流产水肿绒毛、葡萄胎及侵袭性葡萄胎的辅助诊断及鉴别诊断的有效指标。

Objective To approach expressions of ER and PR in hydatidiform mole tissues and its clinical significance.Method The expressions of ER and PR were detected in 20 chorionic villus of early pregnancy,20 villous edema,28 partial hydatidiform,35 complete hydatidiform and 9 invasive hydatidiform by immunohistochemisty.Results The positive rate of ER in normal villous,villous edema,partial hydatidiform,complete hydatidiform and invasive hydatidiform was 90.0% 、95.0% 、67.9% 、65.7% 、22.2% respectively.As the degree of malignancy increased,the number and intensity of ER was decreased（P 0.05）.The positive rate of PR in normal villous,villous edema,partial hydatidiform,complete hydatidiform and invasive hydatidiform was 5.0% 、10.0% 、3.6% 、2.9% 、0% respectively.The expression of PR was low in normal villous,villous edema,partial hydatidiform,complete hydatidiform and was negative in invasive hydatidiform.The expression of PR had not correlation with degree malignancy of trophoblastic cells（P 0.05）.Conclusion ER could be an effective marker for diagnosis and differential diagnosis of normal villous,villous edema,partial hydatidiform,complete hydatidiform and invasive hydatidiform.