喷雾干燥法制备壳寡糖/水杨酸微胶囊

Preparation of Chito-oligosaccharide/Salicylic Acid Microcapsules by Spray-drying

采用喷雾干燥法制备壳寡糖/水杨酸微胶囊,以微胶囊的含油率和包结率为指标,通过单因素及正交实验优化得到的制备工艺为:壳寡糖质量分数2%,壳寡糖与水杨酸质量比为1.0∶0.5,进风温度(170±2)℃,出风温度(90±2)℃,进料泵速6.6 mL/min,风压和风速分别为40 m3/h和667 L/h,得到的产品含油率和包结率分别是19.1%和21.5%。红外光谱分析表明,壳寡糖与水杨酸存在分子间的相互作用;热重差热表征结果表明,经壳寡糖微胶囊化的水杨酸热稳定性得到明显提高。

Chito-oligosaccharide/salicylic acid microcapsules have been prepared by spray-drying method and the preparation conditions were optimized using the single factor study and orthogonal experiment design with oil content and complex content of the mierocapsules as indexes. The optimized parameters of the spray-drying processes were as follows ： w （ chito-oligosaccharide ） = 2% , m （ chito- oligosaccharide） ：m （ salicylic acid） = 1.0：0.5, inlet and outlet air temperatures （ 170 ± 2 ） ℃ and （90±2） ℃, rotational speed of pump feed = 6.6 mL/min, the aspirator rate 40 m3/h and the air flow rate 66. 7 L/h. Under such conditions ,the oil content and complex content of the product were 19. 1% and 21.5%, respectively. A procedure based on FTIR was used to detect the presence of salicylic acid in the chito-oligosaccharide/salicylic acid microcapsules. TG-DSC results confirmed that the thermal stability of salicylic acid was significantly improved after the microcapsule formation was completed.