肺癌患者D-二聚体水平的临床分析

Clinical analysis of D-dimer level of patients with lung cancer

目的探讨肺癌患者D-二聚体水平的临床意义。方法测定60例肺部良性疾病患者、80例肺癌患者及30例正常对照组的D-二聚体水平,分别进行比较分析。结果肺癌组D-二聚体水平均明显高于肺部良性疾病组及正常对照组(P<0.05),肺癌组临床分期Ⅲ-Ⅳ期患者D-二聚体水平明显高于Ⅰ-Ⅱ期患者(P<0.05),肺癌转移组D-二聚体水平明显高于无转移组(P<0.05)。结论 D-二聚体的测定对肺癌与良性疾病的鉴别诊断、临床分期、有无转移及预后具有一定参考价值。

Objective To explore the clinical significance of D-dimer level of patients with lung cancer. Methods The D-dimer level was measured in 60 patients with benign lung disease, 80 patients with lung cancer, and 30 healthy people. Results The D-dimer level was obviously higher in the lung cancer group than in the benign group and the control group （ P 〈0.05 ）. The D-dimer level was ob- viously higher in patients with lung cancer at stage Ⅲ-Ⅳ than at stage Ⅰ-Ⅱ （P 〈 0. 05 ）. It was also obviously higher in the lung cancer metastasis group than those without metastasis （ P 〈 0.05）. Conclusion The determination of D-direct can provide certain reference to diagnosis, differentiation, and metastasis.