BiPAP联合硫酸镁对肺心病患者血浆NT-proBNP和ET-1的影响

Influence of BiPAP combined with magnesium sulfate on serum NT-proBNP and ET-1 in patients with pulmonary heart disease

目的探讨无创双水平气道正压通气(BiPAP)联合硫酸镁对肺心病急性加重期患者血浆N末端B型脑钠肽(NTproBNP)和内皮素-1(ET-1)的影响。方法 96例肺心病急性加重期患者随机分为两组,对照组48例,观察组48例,对照组采用常规治疗,观察组在常规治疗的基础上加用BiPAP联合硫酸镁治疗。治疗前后测定患者平均肺动脉压力(MPAP),血浆NTproBNP和ET-1。结果两组患者治疗后观察组比对照组MPAP下降更明显(P<0.05);两组治疗后观察组比对照组血浆NTproBNP和ET-1降低更明显(P<0.05)。结论采用BiPAP联合硫酸镁治疗急性期肺心病患者可以减轻血浆NT-proBNP和ET-1的表达。

Objective To explore the influence of nonlnvasive BiPAP combined with magnesium sulfate on serum N-terminal pro- B-type brain natriuretic peptide （NT-proBNP） and endothelin （ ET-1 ） in patients with pulmonary heart disease at acute exacerbation. Methods 96 patients with severe bronchial asthma were randomly divided into two groups, the observation group （ n = 48 cases） and the eantrol group （n = 48 eases）. All patients were given conventional treatment, and the observation group was additionally treated with non- invasive BiPAP plus magnesium sulfate. The mean pulmonary arterial pressure （ MPAP）, serum NT-proBNP and ET-1 were detected. Re- sults MPAP decreased more obviously in the observation group than in the control group after the treatment （ P 〈 0.05 ）. The levels of serum NT-proBNP and ET-1 were obviously lower in the observation group than in the control group （P 〈 0. 05）. Conclusion Noninva- sire BiPAP combined with magnesium sulfate can decrease serum NT-proBNP and ET-1 in the treatment of patients with pulmonary heart disease at acute exacerbation.