呼出气一氧化氮在哮喘诊断中的价值及与肺功能相关性

Application of exhaled nitric oxide in the diagnosis of asthma and its correlation with lung function

目的阐明呼出气一氧化氮(eNO)在不同呼吸系疾病的诊断价值及哮喘患者中eNO与不同肺功能结果的相关性。方法呼吸系疾病患者共398人,同时检测eNO值、FEV1%预计值、支气管舒张试验。结果哮喘eNO值明显高于其他呼吸系疾病eNO值。哮喘患者中支气管舒张试验阳性组eNO≥50 ppb占53.8%;支气管舒张试验阴性组eNO<50 ppb占63.4%。按肺功能严重度分组,各组间eNO值无明显差异。结论 eNO是诊断哮喘可靠的标志物之一;哮喘患者中eNO值与支气管舒张试验结果存在一定相关性,与肺功能严重度无明显关联。

Objective To evaluate the exhaled nitric oxide （eNO） in the diagnosis of different respiratory diseases and to investi- gate its relationship with lung function in patients with asthma. Methods 398 patients with different respiratory diseases were selected in this study, and their eNO and FEV1% were measured. Bronchial dilation test was also performed in all patients. Results The level of eNO was significantly higher in patients with asthma than in other respiratory diseases. There were 53.8% of the patients with eNO higher than or equal with 50 ppb in asthma patients through positive bronchial dilation test. In the negative bronchial dilation test, there was 63.4% of the patients with eNO lower than 50ppb. Conclusion eNO is a reliable marker in the diagnosis of asthma. In patients with asthma, eNO has a certain correlation with the results of bronchial dilation test, but it has no relation with the severity of lung function.