慢性阻塞性肺病并发静脉血栓栓塞危险因素分析

Analysis of risk factors of chronic obstructive pulmonary disease complicated with venous thromboembolism

目的探讨COPD发生静脉血栓栓塞症(VTE)的高危因素与预防对策。方法分析我院呼吸内科诊断为COPD并发VTE的65例住院患者的临床资料,实验组(COPD合并VTE组)和对照组(COPD无VTE组)就年龄、长期卧床、其他合并症、长期吸烟、低氧血症、长期口服或静脉糖皮质激素、COPD急性加重频繁、深静脉置管等多种因素进行组间比较,采用χ2检验两组间的差异性。结果实验组与对照组比较,长期卧床(>7天)、COPD急性加重频繁(>3次/年)、长期口服或静脉应用激素和深静脉置管,经χ2检验,P<0.05,差异具有统计学意义。结论长期卧床、COPD急性加重次数频繁、长期口服和静脉应用激素和深静脉置管是COPD并发VTE的高危因素。

Objective To investigate the high risk factors and preventions for COPD patients complicated with venous thromboem- belism. Methods The clinical data of 65 COPD patients complicated with VTE were retrospectively analyzed. The differences of age, stay in bed, other complications, long-term smoking, hypoxemia, long-term oral or intravenous glucoeortieoid therapy, frequent exacerba- tions of COPD, deep venous catheters and other factors were compared between the two groups by X2 test. Results There were significant differences on long stay in bed （ 〉7 days）, frequency of acute exacerbation （ 〉3 times/year）, long-term oral or intravenous steroid and deep vein tube indwelling between the two groups （ P 〈 0. 05 ）. Conclusion The high risk factors of COPD patients complicated with VTE include long stay in bed, frequent exacerbations of COPD, long-term oral or intravenous steroid and deep venous catheter.