巨细胞病毒感染与早产儿支气管肺发育不良的相关性探讨

Study on correlation between cytomegalovirus infection and premature infants with bronchopulmonary dysplasia

目的探讨临床巨细胞病毒(CMV)感染与早产儿支气管肺发育不良(BPD)的关系。方法选取我院收治的42例支气管肺发育不良的早产儿作为观察组,另选取在我院生产的42例非支气管肺发育不良的早产儿作为对照组,通过酶联免疫吸附测定实验(ELISA)检查两组早产儿血清中的CMV-IgM及CMV-IgG抗体情况,比较两组早产儿发生巨细胞病毒感染情况。结果检测结果显示观察组早产儿巨细胞感染率显著高于对照组,(P<0.01);而临床症状感染率观察组较对照组明显升高(P<0.05),有统计学意义。结论 CMV感染,尤其是症状性感染是引起早产儿BPD的重要因素之一。

Objective To investigate the relationship between clinical cytomegalovirus （ CMV ） infection and premature infants with bronchopulmonary dysplasia （BPD）. Methods 42 preterm infants with bronchopulmonary dysplasia were selected as the observation group, and another 42 preterm infants without bronchopulmonary dysplasia were selected as the control group. CMV-IgM and CMV-IgG an- tibodies were measured by enzyme-linked immunosorbent assay （ELISA） examination in the two groups. Cytomegalovirus infection was compared between the two groups. Results The test results showed that the incidence of cytomegaiovirus infection was significantly higher in the observation group than in the control group （P 〈0. 01 ）, and the clinical infection rate was significantly higher in the observation group than in the control group （ P 〈 0. 05 ）. Conclusion CMV infection, especially symptomatic infection, is one of the important fac- tors of causing BPD in premature infants.