皮肤鳞状细胞癌中Axl、NF-κB的表达及意义

Expression of Axl and NF-κB in Cutaneous Squamous Cell Carcinoma and Its Significance

目的观察Axl(Aexekleto)、真核转录因子-κB[NF-κB(P65)]在正常皮肤组织和皮肤鳞状细胞癌(SCC)组织中的表达情况及特点,并探讨其在皮肤SCC发生发展中可能的意义。方法采用免疫组化SABC法检测20例正常皮肤组织及40例皮肤SCC中Axl、NF-κB(P65)的表达。结果 Axl在皮肤SCC组织和正常皮肤组织中的阳性表达率分别是87.5%和0%,两者相比差异有统计学意义(χ2=42.0,P<0.05)。NF-κB(P65)在皮肤SCC组织和正常皮肤组织中阳性表达率分别为82.5%和10.0%,两者相比差异有统计学意义(χ2=28.83,P<0.05)。Axl及NF-κB(P65)在皮肤SCC中的表达等级相关系数rs=0.224,P=0.165,差异无统计学意义。结论 Axl介导的信号通路可能在皮肤SCC的发生发展过程中发挥一定的作用。

Objective To examine the expression of Axl and NF-κB（P65） in cutaneous squamous cell carcinoma （SCC） and normal skin tissues and its significance in the development of SCC. Methods Expression of Axl and NF-κB（P65） was immunohistochemically detected in 40 SCC tissues and 20 normal skin tissues. Results The positive expression rate of Axl was 87.5 % in SCC tissues and 0% in normal skin tissues and there was a significant difference （P〈0.05）. The positive expression rate of NF-κB（P65） was 82.5% and 10.0% in the two groups,respectively （P〈0.05）. No correlation between Axl and NF-κB（P65） was found in SCC tissues. Conclusion The aberrant over-expression of Axi and NF-κB may play an important role in the occurrence and develooment of SCC.