降钙素原在新生儿感染性肺炎早期诊断中的应用

Application of Procalcitonin in Early Diagnosis of Neonatal Pulmonary Infection

【目的】探讨血清降钙素原（procalcitonin，PCT）在新生儿感染性肺炎早期诊断中的应用。【方法】选择本院新生儿科在2009年3月至2012年11月收治的102例新生儿感染性肺炎患儿，其中细菌感染患者77例（细菌组），病毒感染患者25例（病毒组），另选同期102例正常足月新生儿作为对照组。【结果】细菌组的血清PCT、C-反应蛋白（CRP）和外周血白细胞（WBC）均显著地高于病毒组和对照组（P〈0．05）；病毒组的血清PCT、CRP和WBC水平均显著地大于对照组（P〈0．05）；血清PCT诊断脓毒血症的敏感性、特异性、阳性预测值和阴性预测值均明显大于血清CRP和WBC（P〈0．05），并且血清CRP的敏感性，特异性、阳性预测值和阴性预测均显著地大于wBC（P〈0．05）。【结论】血清PCT是诊断新生儿感染性肺炎的可靠指标，值得临床推广。

[Objective] To explore the application of serum procalcitonin（PCT） in early diagnosis of neonatal pulmonary infection. [Methods] A total of 102 children with neonatal pulmonary infection in neonatology department of our hospital from March 2009 to Nov. 2012 were chosen. Among them, 77 patients were bacterial infection（bacterial group） and 25 patients were virus infection（virus group）. Other 102 normal full-term newborns（control group） were taken as control group. [Results] The levels of serum PCT and C-reactive protein（CRP） as well as white blood cell（WBC） in peripheral blood of bacterial group were significantly larger than those in virus group and control group（ P〈0. 05）, and those in virus group were larger than those in control group（ P 〈0.05）. The sensitivity, specificity, positive predictive value and negative predictive value of serum PCT in diagnosing neonatal pulmonary infection were significantly larger than those of serum CRP and WBC（ P 〈0.05）, and those of serum CRP in diagnosing neonatal pulmonary infection were larger than those of WBC（ P 〈0.05）. [Conclusion] Serum PCT is a reliable index for diagnosing neonatal pulmonary infeetion. It is worthy to be popularized.