ITP患者促血小板生成素与T淋巴细胞亚群的相关性分析

Analysis of the Relationship Between Thrombopoietin and T-lymphocyte Subsets in ITP Patients

【目的】探讨免疫性血小板减少性紫癜（ITP）患者促血小板生成素（TP0）与T淋巴细胞亚群的相关性。【方法】采用大剂量地塞米松治疗ITP患者（治疗组），根据疗效分为有效组和无效组，同时收集健康志愿者（对照组），检测各组外周血循环中TPO、血小板巨核细胞数量及T淋巴细胞亚群，并分析TPO与T淋巴细胞亚群的相关性。【结果】治疗组中有效组TP0明显低于无效组（P〈0．05）；相关分析表明激素治疗有效组患者血清TPO水平与PLT、巨核细胞数呈负相关；与正常对照组相比，ITP组CD3＋和CD4＋明显下降，CD8＋明显升高，CD4＋／CD8＋比例明显下降，ITP激素治疗有效组T淋巴细胞亚群变化与正常对照组比较差异无显著性，CD4＋、CD8＋、CD3＋的含量与PLT存在相关性；激素治疗有效患者血清TPO和血小板水平与CD4＋、CD8＋、CD3＋舍量存在相关性。【结论】ITP患者TPO水平与T淋巴细胞亚群的变化有关。

[Objective] To explore the correlation between thrombopoietin（TPO） and T-lymphocyte subsets in patients with immunologic tbrombocytopenic purpura（ITP）. [Methods] ITP patients（treatment group） received high dose dexamethasone（HD-DXM） and were divided into effective subgroup and ineffective sub-group according to the efficacy. Meanwhile, healthy volunteers（control group） were collected. TPO in peripheral blood, the number of platelet（PLT） and megakaryocytes and T-lymphocyte subsets in all groups were detected. The correlation between TPO and T-lymphocyte subsets was analyzed. [Results]TPO in effective sub- group of treatment group was obviously lower than that in ineffective subgroup（ P 〈0.05）. The correlation a and megakaryocytes. Compared with normal control group, CD3＋ and CD4＋ in ITP group were decreased obviously, and CD8＋ was increased obviously, and CD4＋/CD8＋ ratio was decreased obviously. There was no significant difference in the change of T-lymphocyte subsets between hormone effective subgroup and normal control group. The levels of CD4＋ , CD8＋ and CD3＋ were associated with PLT. Serum TPO and PLT in hormone effective subgroup were associated with the levels of CD4＋ , CD8＋ and CD3＋. [Conclusion] TPO level in ITP patients is associated with the change of T-lymphocyte subsets.