摘要
相邻细胞间最主要最快速的通讯方式是缝隙连接通道(GJ),而缝隙连接蛋白(Cx)形成的连接子是其主要组成部分。Cx大多属于磷蛋白,其磷酸化状态不同程度地影响其自身的合成装配以及GJ的功能。Cx43是哺乳动物身上分布最广泛的Cx,尤其是在心血管系统和神经系统,它的磷酸化状态受到多重激酶途径调节,发生磷酸化的位点也不尽相同,且Cx43的磷酸化参与了多种疾病的发生、发展。
Gap junction（G J）is the most main and rapid communication way between adjacent cells, which is composed by connexin （Cx）. Connexins mostly belong to the phosphoprotein. The phosphorylation status influences its own synthesis assembly and the function of the GJ. Cx43 is the most widely distributed connexin in mammals, especially in the cardiovascular system and nervous system. Various kinases involved in the regulation of Cx43 phosphorylation, and phosphorylation site is different, and the Cx43 phosphorylation is involved in a variety of disease development.
出处
《医学综述》
2013年第19期3463-3466,共4页
Medical Recapitulate
基金
国家自然科学基金(81060099)
