循环肿瘤细胞检测在肺癌临床应用中的研究进展

Research Progress in the Clinical Application of Detection of Circulating Tumor Cells in Lung Cancer

随着近些年研究的逐步深入,已发现循环肿瘤细胞(CTCs)与肿瘤的侵袭、转移存在密切联系,且能够预测预后及指导个体化治疗。目前多种检测CTCs的方法已被广泛应用于临床研究中。而肺癌作为最常见的恶性肿瘤,因其敏感性相对较低及检测方法不统一等问题,在CTCs的研究中目前尚处于初级阶段。但是随着大样本多中心研究的展开,未来CTCs也将在肺癌的诊断治疗等领域中占据重要地位。该文对近年来CTCs在肺癌领域研究的最新相关进展进行综述。

With the progress in studies in recent years, circulating tumor cells（CTCs） have been found to have close connection with the invasion and metastasis of solid tumor,which can predict the tumor prognosis and direct the individualized therapy as well. Nowadays, plenty of detection techniques of CTCs have been applied in clinical research, whereas the lung cancer, as the most common malignant tumor, is still in its primary stage of CTCs research, because of its low sensitivity and non-unified detection techniques. As the larger sample and multicentric studies are being developed, it is sure that CTCs will play an important role in the diagnosis and treatment of lung cancer. Here is to make a review of the recent progress of CTCs in lung cancer research field.