阿立哌唑与齐拉西酮治疗精神分裂症283例疗效分析

Efficacy Analysis of Aripiprazole and Ziprasidone in the Treatment of 283 Cases of Schizophrenia

目的比较阿立哌唑(安律凡)与齐拉西酮(力复君安)治疗精神分裂症的疗效与不良反应。方法选取2009年1月至2013年1月在解放军422中心医院心理专科门诊就医的283例精神分裂症患者,按随机数字表法分为治疗组159例(口服阿立哌唑治疗)和对照组124例(口服齐拉西酮治疗),疗程8周。采用简明精神病量表(BPRS)和不良反应量表(TESS)在治疗前和治疗后第2、4、8周末进行疗效及不良反应的量化评定。在治疗第8周末,依据医学疾病疗效4级评定标准对两组患者的临床疗效进行评定。在治疗前和治疗后第2、4、8周末分别进行血、尿、肝功常规和心电图检查。结果两组患者在治疗后第2、4、8周末的BPRS总分及各因子评分均比治疗前显著降低(P<0.05)。但两组之间各个时间段只有BPRS总分及焦虑忧郁因子评分的差异有统计学意义(P<0.05),其余各因子评分两组之间比较均无统计学意义(P>0.05)。两组患者治疗后2、4、8周的TESS总分经统计学处理比较均无统计学意义(P>0.05),两组TESS总分均以治疗后2周最高,治疗后8周最低。在治疗前和治疗后第2、4、8周末,血、尿、肝功能常规和心电图检查均未发现异常。治疗8周后,两组患者治疗效果比较,差异无统计学意义(P>0.05)。结论口服阿立哌唑和齐拉西酮治疗精神分裂症,均可显著改善患者症状,其疗效确切、药物不良反应少,具有较好的临床应用价值。以阿立哌唑疗效稍高而药物不良反应更轻,患者有更好的服药依从性。

Objective To compare the efficacy and adverse effeets of aripiprazole and ziprasidone in the treatment of schizophrenia. Methods During Jan. 2009 and Jan. 2013,283 cases of outpatients with schizophrenic from PLA No. 422 Central Hospital were divided randomly into aripiprazole group of 159 patients and ziprasidone group of 124 patients, receiving 8 weeks of treatment. The Brief Psychiatric Rating Sale（BPRS） and the Treatment Emergent Symptom Scale （TESS）were adopted for curative effect and side effects of quantitative evaluation before treatment and at the 2＂＇1,4h ,8d＇ weekend after the treatment started. At the 8th weekend, the elinical efficacy of the two groups was assessed according to medical disease curative ettct of 4 grade evaluation criteria. All patients had the regular blood, urine, liver function test and electrocardiogram examination. Results BPRS total score and factor points of the two groups after treatment we signifieantly lower than before treatment ,the differenee was statistically significant（ P 〈0.05 ）. But each time only BPRS total score and anxiety-depression factor score of the two groups was statistically significantly different（P 〈 0.05 ）, the rest of the comparison faetors of the two groups had no statistical significance（ P 〉0.05 ）. The TESS total score at the 2tha ,4th, and 3thh weekend of the two groups had no statistically significant difference after statistics processing（P 〉 0.05 ）. TESS score at 2 weeks after treat- ment was the highest,at 8 weeks after treatment was the lowest. Before and 2,4,8 weeks idler treatment, blood, urine,liver function test were regular, and ECG result was normal as well. After 8 weeks treatment, there was no statistically significant difference in therapeutic effect between the two groups（ P 〉 0.05 ）. Conclusion The use of aripiprazole and ziprasidone as treatment of schizophrenia can significantly improve symptoms, with definite effects and less side effeets, tberetbre have good clinical application value. Aripiprazole has slightly higher curative effett and lighter drug adverse effeets,and better medica- tion compliance.