肺癌患者化疗期间院内感染的临床特点及危险因素

Clinical Features of Nosocomial Infections in Patients with Lung Cancer Receiving Chemotherapy and Analysis of the Risk Factors

目的探讨肺癌患者化疗期间罹患院内感染的临床特点及其危险因素。方法回顾性分析2010年6月至2012年5月在防城港市第一人民医院接受肿瘤化疗的118例肺癌患者的临床资料,描述入组患者院内感染的临床特征,分析潜在的院内感染危险因素。结果 41.5%(49/118)的患者在化疗期间发生院内感染,上呼吸道和肺部是主要感染部位,占所有感染的85.7%(42/49),真菌及革兰阴性菌为主要病原体,占所有检出病原体的84.2%(16/19);中性粒细胞降低的患者院内感染发生率显著增高(P<0.05)。结论肺癌患者在化疗期间的院内感染率相对较高,中性粒细胞的降低与患者院内感染的罹患风险相关。

Objective To study the clinical features of nosocomial infections in patients with lung cancer receiving chemotherapy,and investigate the related risk factors. Methods A total of 118 patients with lung cancer treated with chemotherapy at Fangchenggang First People＇s Hospital during June 2010 and May 2012 were retrospectively investigated, the clinical tatures of nosocomial intections were described, and the potential risk factors of nosocomial infection were explored using statistical methods. Results 41.5% （49/118 ） of the patients suffered nosocomial infections during the process of chemotherapy, upper respiratory tract and lung were found as the primary sites of the infections, accounting for 85.7% （42/49） of all the infections,fungi and Gram-negative bacteria were idenlified as he major pathogens, accounting for 84.2% （16/19） of the detected pathogens,the incidence of nosocomial in tections was increased significantly in the patients with a low level of neutrophil（ P 〈 0.05 ）. Conclusion Tie rate of nosocomia infections in the lung cancer patients receiving chemotherapy is relative high, and a decrease of neutrophil may be correlated with a higher risk of nosocomial infections.