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线粒体ATP敏感性钾通道及其神经保护作用机制的研究进展 被引量：4

Research Progress of Mitochondrial ATP Sensitive Potassium Channels and Its Mechanisms of Neuroprotection
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摘要 大量药理学和生物学研究已证实,ATP敏感性钾通道(K ATP)的开放在多种组织细胞损伤中发挥着重要的保护作用,其对脑的保护作用研究正逐渐成为研究热点。目前发现细胞上主要存在两种K ATP:质膜表面K ATP(sK ATP)和细胞质内的线粒体膜K ATP(mitoK ATP)。已有研究证明,mitoK ATP对K ATP开放剂的敏感程度是sK ATP的近2000倍,这预示着mitoK ATP在脑保护作用中可能发挥着更大的作用。 Activation of the ATP-sensitive potassium channel（ KATv ）has been widely implicated in cyto- protection. Recently,researchers are focusing on its neuroprotection. ATP sensitive potassium chanuels are located in various parts of the cells, including the surface of the plasmalemmal membrane （ SKATP ） and the inner mitochondrial membrane（ mitoKATP ）. [t has been proven thai mitoKAy, is 2000 times more sensitive than sKvrP. Therefore,it implies that mitOKATP channels may play a more important role in neuroprotection.
作者 罗红凤 林霓阳
机构地区 汕头大学医学院第一附属医院儿科
出处 《医学综述》 2013年第20期3658-3660,共3页 Medical Recapitulate
基金 2011年广东省自然科学基金(S2011010005065) 汕头市科技计划项目(汕市财教〔2011〕134号第180项)
关键词 线粒体ATP敏感性钾通道 开放剂 神经保护 mitoKATP channels Openers Neuroprotection
分类号 R722 [医药卫生—儿科]
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参考文献28

  • 1Noma A. ATP-regulated K + channels in eardiae muscle[J]. Nature, 1983,305 ( 593(I ) : 147-148.
  • 2lnoue LNagase H, Kishi K,et -l. ATP-nsitive K + channel in the milCx:hondrial inner membrane[ J ]. Nature, 1991,352(6332) :244-247.
  • 3Bajgar R,Seetharaman S, Kowahowski AJ,et al. Identification and prnperlies of a novel intraceliular (miloehondrial) STP-sensi|ive potassium channel in brain[J] J Biul Chem, 2001,276 ( 36 ) : 33369-33374,.
  • 4Robin E, Simerabet M, l tassuun SM, et al. Poslc-mditioning in t'ucal cerebral ischemia:rnle nf the mituchondrial ATP-dependent pntas- slum cha,,nel [J]. Brain Res, 201 I, 1375 : 137-146.
  • 5Ohmasa F,Saito M, Oiwa H ,et al. Pharmaeulogieal preconditioning of ATP-sensitive potassium channel openers on acute urinary reten- tion-induced bladder dysfunction in the rat [ J ]. BJU Int,2012,110 ( 6 Pt B ) : E245-E252.
  • 6Wu Q, Tang C, Zhang YJ, et al. Diazoxide suppresses hepatic ischemia/reperfusion injury atier mouse liver transplantation by a BCL-2-dependent mechanism [J]. J Surg Res, 2011 , 169 ( 2 ) : e155-e166.
  • 7Singh H,14udman D ,Lawrence CL,et aL Distribution of Kit6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventric-ular myocytes [ J ]. J Mol Cell Cardio1,2003,35 ( 5 ) :445-459.
  • 8Foster DB ,Rucker JJ ,Mm'ban E. Is Kir6. 1 a subunit -ff nfitoK(ATP) ?[J]. Bic-',hem Biophys Res Commun ,2008,366(3) :649-656.
  • 9Kuniyasu A, Kaneko K, Kawahara K,et al. Molecular assembly and subcellular distribution of ATP-sensitive potassium channel pro- teins in rat hearts[J]. FEBS Lett,2003,552(2/3 ) :259-263.
  • 10Ye B,Kroboth SL, Pu JL,et al. Molecular identification and func- tional characterization of a mitochondrial sulfonylurea receptor 2 splice variant generated by intraexonic splicing[ J]. Circ Res ,2009, 105( 11 ) :1083-1093.

二级参考文献14

  • 1Rajapakse N,Shimizu K,Kis B,et al. Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats[J]. Neurosci Lett,2002,327(3):208-212.
  • 2Guo J,Meng F,Zhang G,et al. Free radicals are involved in continuous activation of nonreceptor tyrosine protein kinase c-Src after ischemia/reperfusion in rat hippocampus[J]. Neurosci Lett,2003,345(2):101-104.
  • 3Zweier JL,Flaherty JT,Weisfeldt ML. Direct measurement of free radical generation following reperfusion of ischemic myocardium[J]. Proc Natl Acad Sci USA,1987,84(5):1404-1407.
  • 4Pain T,Yang XM,Critz SD,et al. Opening of mitochondrial KATP channels triggers the preconditioned state by generating free radicals[J]. Circ Res,2000,87(6):460-466.
  • 5Tritto I,D'Andrea D,Eramo N,et al. Oxygen radicals can induce preconditioning in rabbit hearts[J]. Circ Res,1997,80(5):743-748.
  • 6Balestrino M. Pathophysiology of anoxic depolarization:new findings and a working hypothesis[J]. J Neurosci Methods,1995,59(1):99-103.
  • 7Di Loreto S,Balestrino M. Development of vulnerability to hypoxic damage in vitro hippocampal neurons[J]. Int J Dev Neurosci,1997,15(2):225-230.
  • 8Marber MS. Ischemic preconditioning in isolated cells[J]. Circ Res,2000,86(9):926-931.
  • 9Dana A,Skarli M,Papakrivopoulou J,et al. Adenosine A1 receptor induced delayed preconditioning in rabbits:induction of p38 mitogen-activated protein kinase activation and Hsp27 phosphorylation via a tyrosine kinase-and protein kinase C-dependent mechanism[J]. Circ Res,2000,86(9):989-997.
  • 10Takashi E,Wang Y,Ashraf M. Activation of mitochondrial KATP channel elicits late preconditioning against myocardial infarction via protein kinase C signaling pathway[J]. Circ Res,1999,85(12):1146-1153.

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医学综述
2013年 第20期

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