摘要
作为体内具有最强收缩血管能力的物质,尾加压素Ⅱ(UⅡ)及其受体(UT)组成的尾加压素系统参与多种疾病的病理生理发展过程。UⅡ/UT系统在人体内广泛分布于中枢神经系统、心血管系统、胰腺和肾脏等处。因此,UT拮抗剂被认为是治疗相关疾病的潜在靶点。该文就肽类和非肽类UⅡ受体拮抗剂的特点及其在心脑血管疾病、糖尿病、糖尿病肾病和高血压病等疾病的研究进展予以综述。
Known as a substance with the most powerful vasoeonstrietor,urotensin II （U II ）and uroten- sin II receptor（UT） consisted system plays a significant role in the pathophysiology of many diseases. U III/UT system distribute in lots of organs such as;central nervous system, cardiovascular system,pancreas and kidney and so on. Thus a large number of researchers think that the antagonist of UT will be a new and potential target to treat many illnesses. Here is to make a review of the characteristic of the antagonist of UT in two big speeies：peptide and non-peptide,and their use in the research of diabetes, diabetic nephropathy,and hyper- tension etc..
出处
《医学综述》
2013年第20期3679-3682,共4页
Medical Recapitulate
