创伤性颅脑损伤中白细胞介素的研究进展

Research Progress in Interleukin Cytokine Expression in Traumatic Brain Injury

白细胞介素是一类能在细胞间传递信息、具有免疫调节和效应功能的蛋白质或小分子多肽。同种白细胞介素在不同损伤患者或同一患者不同阶段发挥的作用不同,其对颅脑损伤引起的继发性脑缺血有加重损伤作用,参与中枢神经系统感染、炎症、外伤、自身免疫、局部缺血的机体防御反应,可通过抗炎和抗凋亡作用而发挥神经保护作用。白细胞介素参与颅脑损伤是近年研究的一个新动向,其在颅脑损伤后的作用己经被证明。

Interleukin is a species of proteins or small peptides with the function of information transmis- sion between cells, immune regulation and effect function. One interleukin may play different roles in different injury patients or same patients at different stages, which has aggravating damaging effect on secondary brain ischemia caused by craniocerebral trauma. Interleukin participates in the central nervous system infection, inflammation,trauma, autoimmune, ischemic defense response, playing a neuroprotective role through the action of anti-inflammatory and anti-apoptotic effect. Interleukin cytokines involvement in traumatic brain injury is a recent new trend in the field,the role of which in the brain injury has been proved.