Toll样受体与2型糖尿病及其并发症的关系及分子机制

Relationships and Molecular Mechanisms of Toll-like Receptors and Type 2 Diabetes and Its Complications

Toll样受体(TLR)是固有免疫系统的一类重要受体,通过识别病原体相关的分子模式诱导机体产生炎性反应,而炎症是2型糖尿病及其并发症的重要病理生理过程。TLR参与2型糖尿病患者的胰岛素抵抗、β细胞功能障碍及并发症的发生和发展,其机制可能包括2型糖尿病患者体内存在的糖脂代谢紊乱持续激活TLR,诱导活性氧和细胞因子产生增加,并最终导致炎性反应。对TLR认识的进一步深入,将为2型糖尿病的抗炎性治疗和免疫干预提供新的思路。

Toll-like receptors（TLR） are an important class of receptors of the innate immune system. Its activation can induce inflammatory response by recognizing pathogen associated molecular patterns while inflammation is an important pathophysiological process of type 2 diabetes and its complications. Studies have shown that TLR is involved in the development of insulin resistance and ~ c.ell d~,＇sfunction of type 2 diabetic patients and its complications. The mechanism may include the glucose and lipid disorders involved in type 2 diabetes sustained activation of TLR,induction of reactive oxygen species and cytokine production increase, which eventually lead to the inflammatory response. The further understanding of TLRs would provide new methods of anti-inflammation therapy and immune intervention for type 2 diabetes mellitus.