摘要
还原型烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶是一种广泛存在的过氧化物酶,其催化产物活性氧参与了机体细胞防御、分化、增殖、凋亡等生理过程。然而在病理状态下,NADPH氧化酶过度激活、参与蛋白激酶C(PKC)调节、晚期糖基化终末产物(AGEs)通路、多元醇途径、己糖胺途径等进程,造成血管内皮损伤、血流供应减少及神经组织破坏等,促使糖尿病慢性并发症的形成和发展。因此,抗氧化应激治疗在糖尿病慢性并发症防治过程中具有重要作用。
It is known that NADPH oxidase widely exists. Reactive oxygen speeies, the eatalysate of N ADPH oxidase,play an important role in body defense,differentiation, proliferation, apoptosis and other physical processes. In pathologic state,excessively activated NADPH oxidase is participant in the egula- tion of protein kinase C, advanced glyeation end products channel, the progression of polyalcohol and hexosamine pathway,causing endothelial dysfunction,reduction of blood supply and destruction of neural tissue,hence contributes to the occurrence and development of chronic diabetie eompfications. Therefore, oxidative stress treatment is vital to the prevention and tatment nf chronic diabetic complications.
出处
《医学综述》
2013年第20期3760-3762,共3页
Medical Recapitulate
