大剂量奥美拉唑治疗20例重症胰腺炎的疗效观察

Efficacy Observation of High-dose Omeprazole Treatment in 20 Patients with Severe Pancreatitis

目的 探讨大剂量奥美拉唑治疗重症胰腺炎的临床疗效.方法 选取2008年1月至2012年6月于延安大学附属医院就诊的40例重症胰腺炎患者作为研究对象,根据随机数字表法分为大剂量组和常规剂量组,每组患者各20例,大剂量组给予静脉滴注大剂量奥美拉唑（80lmg）治疗,常规剂量组患者给予常规剂量奥美拉唑（40 mg）治疗,共给药7～14d,采用SPSS 15.0统计软件对两组患者的临床治疗效果及胃肠道恢复情况、住院时间的数据进行分析比较.结果 大剂量组（n=20）显效14例,有效5例,无效1例,总有效率为95%;常规剂量组（n=20）显效7例,有效5例,无效8例,总有效率60%,两组比较临床疗效,差异有统计学意义（u=6.75,P＜0.05）.大剂量组的胃肠道恢复时间显著短于常规剂量组[（6.9±1.3）pd vs（9.4±1.5）d],住院时间也显著短于常规剂量组[（22.2±13.3）d vs（34.3±14.2） d],比较差异均有统计学意义（P＜0.05）.结论 对重症胰腺炎患者使用大剂量奥美拉唑治疗,可有效的缩短患者的胃肠道恢复时间及住院时间,提高治愈率.

Objective To investigate the clinical efficacy of high-dose omeprazole treatment in severe panereatitis. Methods Forty patients with severe panereatitis in Affiliated Hospital of Yan＇an University were chosen as research subjects. They were randomly divided into study group and control group（ n = 20） patients. The study group was given intravenous infusion of high-dose （80 rag）omeprazole, the control group were treated with conventional doses（40 mg）of omeprazole, administered for 7-14 days. SPSS 15.0 statistic software was used to analyze and compare the clinical efficacy and gastrointestinal recovery and hospitaliza- tion time of the two groups. Results There were 14 case of markedly effective ,5 cases of effective, 1 case of ineffective in the study group,the total effective rate was 95%; there were 7 case of markedly effective,5 cases of effective,8 case of ineffective in the control group,and the total efficiency was 60% ;comparing the two sets of data, the difference was statistically significant（ u = 6.75, P 〈 0.05 ）; in the study group, the gastrointestinal recovery time was（6.9 ＋ 1.3 ） d, hospital stay was（22.2 13.3 ） d, compared with the con- trol group（9.4 1.5 and 34.3 14.2 ） d, there were statistically significant differences（ P 〈 0.05 ）. Con- clusion The use of high-dose omeprazole in patients with severe pancreatitis, can effectively shorten the gas- trointestinal tract recovery time and hospital stay of the patients, and improve the cure rate.