嗜酸粒细胞增高在晚期肺癌预后中的临床意义

Clinical value of increased eosinophil assess prognosis in patients with advanced lung cancer

目的探讨嗜酸粒细胞增高在晚期肺癌预后评估中的价值。方法选择2010年1月至2011年11月在宝鸡市中心医院确诊的756例肺癌患者,根据患者嗜酸粒细胞正常与否分为嗜酸粒细胞增高肺癌组(增高组)121例和嗜酸粒细胞正常肺癌组(正常组)635例。将肺癌的临床分期、病理分型及一年生存率与一年后幸存患者的肿瘤生存质量评分(KPS)进行统计学分析。结果肺癌的临床分期,增高组Ⅳ期的比例明显高于正常组,差异有统计学意义(P<0.01),而正常组Ⅲ期的比例高于增高组,差异有统计学意义(0.01<P<0.05),但增高组晚期(Ⅲ期+Ⅳ期)与正常组比较,无明显差异,差异无统计学意义。肺癌的病理分型,增高组与正常组差异无统计学意义。经过一年的随访,增高组晚期(Ⅲ期+Ⅳ期)的一年生存率、KPS均高于正常组,差异有统计学意义(P<0.01)。结论嗜酸粒细胞增高可能为预测晚期肺癌预后良好的标志。

Objective To investigate the clinical value in increased eosinophil assess prognosis of patients with advanced lung cancer.Methods The clinical datas of 756 patients with lung cancer from January 2010 to November 2011 in Baoji municipal central hospital were retrospectively analyzed.A total of 121 cases were divided into increased eosinophil lung cancer group （increased group） and 635 cases were in normal eosinophil lung cancer group （normal group）,according to eosinophil level.Statistical analysis was made on the index such as the clinical staging,the pathological types of lung cancer,one year survival rate and karnofsky performance status（KPS） score of survival in patients with lung cancer after one year.Results In the Ⅳ clinical stage of lung cancer,the proportion of the increased group was obviously higher than that of normal group,the difference was statistically significant （P 〈0.01）.In the Ⅲ stage,the proportion of the normal group was higher than that of the increased group,the difference was statistically significant （0.01 〈 P 〈 0.05）,but the increased group in the advanced stage （Ⅲ ＋ Ⅳ） compared with the normal group,there was not statistically significant difference.Compared with the different pathological types of lung cancer between the two groups,there was not statistically significant difference.After one year follow-up,one year survival rate and KPS of survival of the increased group in the advanced stage （Ⅲ ＋ Ⅳ） were higher than that of normal group,the difference was statistically significant （P 〈 0.01）.Conclusion The increased eosinophil may be a good symbol in assessing prognosis of advanced lung cancer.