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地西他滨与支持治疗或小剂量阿糖胞苷治疗初诊老年AML的多中心随机Ⅲ期临床试验研究 被引量：4

Multicenter,Randomized,Phase Ⅲ Trial of Decitabine Versus of either Supportive Care or Low-Dose Cytarabine for the Treatment of Older Patients with Newly Diagnosed Acute Myeloid Leukemia
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摘要 1文献来源 Kantarjian HM ,Thomas XG, Dmozynska A, et al. Muhicenter, randomized, open-label, phase Ⅲ trial of Decitabine versus patient choice, with physician advice, of either supportive care or low-dose Cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia [J]. J Clin Oncol, 2012,30（21 ） ：2670-2677.
作者 秘营昌 赵邢力
机构地区 中国医学科学院血液病医院血液学研究所
出处 《循证医学》 CSCD 2013年第5期264-267,共4页 The Journal of Evidence-Based Medicine
关键词 急性髓性白血病 老年 地西他滨 阿糖胞苷 acute myeloid leukemia elderly Decitabine Cytarabine
分类号 R733.71 [医药卫生—肿瘤]
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参考文献6

  • 1Ferrara F. Conventional chemotherapy or hypomethylating agents for older patients with acute myeloid leukaemia? [J]. Hematol Oncol, 2013, Mar 20. doi: 10.1002/hon.2046. [Epub ahead of print].
  • 2Oran B, Weisdorf DJ. Survival for older patients with acute myeloid leukemia: A population-based study [J]. Haematologica, 2012,97(12) : 1916-1924.
  • 3Kantarjian H, Oki Y, Garcia-Manero G, et al. Results of a randomized study of 3 schedules of low-dose Decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia[J]. Blood, 2007,109( 1 ) : 52-57.
  • 4Cashen AF, Schiller GJ, O'Donnell MR, et al. Muhicenter, phase II study of Decitabine for the first-line treatment of older patients with acute myeloid leukemia[J]. J Clin Oncol, 2010, 28(4) :556-561.
  • 5Blum W, Garzon R, Klisovic RB, et al. Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of Decitabine [J]. PNAS, 2010,107(16) : 7473-7478.
  • 6Lubbert M, Ruter BH, Claus R, et all A muhicenter phase I1 trial of Decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy [ J ]. Hematologica, 2012,97 ( 3 ) : 393-401.

同被引文献28

  • 1Juliusson G, Venditti A, Spagnoli A, et al. Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry [J]. Blood,2009,113(18):4179-4187.
  • 2Maurillo L, Venditti A, Spagnoli A, et al. Azacitidine for the treatment of patients with acute myeloid leukemia: report of 82 patients enrolled in an Italian Compassionate Program[J]. Cancer, 2012, 118(4): 1014-1022.
  • 3Robak P, Robak T. Older and new purine nucleoside analogs for patients with acute leukemias[J]. Cancer Treat Rev, 2013, 39(8): 851-861.
  • 4Jin J, Jiang DZ, Mai WY, et al.Homoharringtonine in combination with cytarabine and aclarubicin resulted in high complete remission rate after the first induction therapy in patients with de novo acute myeloid leukemia[J].Leukemia, 2006, 20(8): 1361-1367.
  • 5Jin J, Wang JX, Chen FF, et al. Homoharringtonine-based induction regimens for patients with de-novo acute myeloid leukaemia: a multicentre, open-label, randomised, controlled phase 3 trial[J]. Lancet Oncol, 2013, 14(7): 599-608.
  • 6Zhou DC, Zittoun R, Marie JP. Homoharringtonine: an effective new natural product in cancer chemotherapy[J]. Bull Cancer, 1995, 82(12): 987-995.
  • 7Shun-ichi Kimura,Hidenori Wada,Yuko Ishihara,et al.D-index dose not predict the development of pulmonary infection in acute myeloid leukemia patients undergoing consolidation chemotherapy with high-dose cytarabine[J].Hematology,2014,19(2):107-112.
  • 8Becker PS,Kantarjian H M,Appelbaum,F.R,et al.Retrospective comparison of clofarabine versus fludarabine in combination with high-dose cytarabine with or without granulocyte colony-stimulating factor as salvage therapies for acute myeloid leukemia[J].Haematologica,2013,98(1):114-118.
  • 9Fiegl,M.,Unterhalt,M.,Kern,W,et al.Chemomodulation of sequential high-dose cytarabine by fludarabine in relapsed or refractory acute myeloid leukemia:A randomized trial of the AMLCG[J].Leukemia:Official journal of the Leukemia Society of America,Leukemia Research Fund,U.K,2014,28(5):1001-1007.
  • 10B l w enberg.Sense and nonsense of high-dose cytarabine for acute myeloid leukemia[J].Blood,2013,121(1):26-28.

引证文献4

二级引证文献10

循证医学
2013年 第5期

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