泰乐菌素高产菌株选育研究进展

Advance in Breeding of High Tylosin Producing Strain

泰乐菌素是一类十六元大环内酯类禽畜专用抗生素,因其抗菌谱广及对动物生长的促进作用而被国内外养殖业广泛使用。泰乐菌素高产菌种选育是泰乐菌素发酵技术研究的重点。物理诱变、化学诱变等传统育种方法虽然发展成熟、操作简单,但诱变效率低下,且后续筛选过程繁琐。随着遗传学、分子生物学等学科的发展,利用分子育种技术定向改造泰乐菌素产生菌的生产能力成为高产菌种选育的一种最有效手段。以分子育种为重点,结合各种菌种选育方法,对近年来泰乐菌素高产菌株选育的进展情况进行综述。

Tylosin is a kind of 16-numbered macrolide antibiotic which is exclusively applied in animals. As its and it could, Tylosin is widely used in livestock breeding because of its property of broad spectrum antibiotic and function of promoting animal growth. Breeding of high-yield strain is the emphasis of tylosin fermentation research. Traditional breeding methods such as physical and chemical mutagenesis are simple and mature. However, the efficiency of mutagenesis is very low, and the subsequent screening process is tedious. With the development of genetics and molecular biology, it becomes an efficiency method by using directed evolution of molecular breeding technology to improve the production capacity of tylosin. In this paper, we focused on the molecular breeding progress and combined different breeding methods to review the progress in breeding of high tylosin producing strain in recent years.