螺旋藻多糖抗疲劳作用研究

Study on anti-fatigue effect of Spirulina polysaccharide

研究螺旋藻多糖(Spirulina polysaccharide)的抗疲劳功效。将100只雄性小鼠随机分为螺旋藻多糖低、中、高3个剂量、空白对照和阳性对照组,分别灌胃100、200、300mg/kg体重螺旋藻多糖、生理盐水和500mg/kg体重西洋参粉。每3d称重一次,30d后,测定小鼠爬杆和负重游泳时间,采血分离血清及取组织样,测定血乳酸(BLA)、血尿素氮(BUN)含量、血清乳酸脱氢酶(LDH)活力以及肝糖原(LG)、肌糖原(MG)含量。结果表明:各剂量螺旋藻多糖均能显著延长小鼠的爬杆及负重游泳时间,中、高剂量螺旋藻多糖能显著降低小鼠运动后血清中BLA、BUN的水平,提高LDH活性,增加了肝糖原及肌糖原的储备量。说明螺旋藻多糖具有抗疲劳的作用。

To study the anti-fatigue effect of Spirulina polysaccharide. One hundred male mice of BALB/c were randomly divided into low dose group,middle dose group,high dose group,blank contrl group and positive control group,three rose groups were administered Spirulina polysaccharide at 100,200,300mg/kg body weight,respectively,blank contrl group and positive group were administered physiological saline and American ginseng powder at 500mg/kg body weight. The control group was administered with normal saline by gavage every day for 30 days. Weights in each group of mice were measured every three days. The climbing time, exhaustive swimming time,the blood lactic acid （BLA）, blood urea nitrogen （BUN）,the activity of lactate dehydrogenase （LDH）, muscle glycogen （MG） content and liver glycogen （LG） content in each group of were measured after 30 days. Results showed that all three dose groups could extended climbing and weight- loaded swimming time of mice,comparing with blank control group,middle and high dose groups could effectively decrease the level of BLA and BUN,enhance the activities of LDH,increase in liver and muscle glycogen deposition. In conclusion,Spirulina polysaccharide had obvious effect on anti-fatigue.