胸腺肽联合布地奈德气雾剂治疗儿童支气管哮喘临床分析

Clinical analysis of thymosin combined with budesonide aerosol in the treatment of bronchial asthma in children

目的对胸腺肽联合布地奈德气雾剂治疗儿童支气管哮喘进行疗效观察。方法选取2011年1月至2012年9月凉山州第二人民医院儿科门诊和住院部治疗的150例儿童支气管哮喘患儿作为观察对象,根据治疗方法不同分为观察组(胸腺肽+布地奈德)75例和对照组(布地奈德)75例,比较两组的疗效,哮喘急性发作次数,持续时间,发作程度,慢性持续期日间症状及夜间症状,呼气峰流速(PEF)变异率。结果观察组的总有效率高于对照组(x^2=14.52,P<0.05)。观察组的哮喘发作次数,发作持续时间短于对照组(t值分别为-5.75和-7.63,均P<0.05),发作程度较对照组轻(秩和检验Mann-Whitney u=52.5,P<0.05)。慢性持续期日间症状、夜间症状、呼气峰流速(PEF)变异率好于对照组(P<0.05)。结论胸腺肽联合布地奈德气雾剂治疗儿童支气管哮喘疗效更佳,值得推广应用。

Objective To study the efficacy of thymosin combined with budesonide aerosol in the treatment of bronchial asthma in children . Methods All 150 children with bronchial asthma , treated in the outpatient and inpatient of the department of pediatrics in the Second People＇s Hospital of Liangshan City, were randomly divided into observation group （budesonide aerosol combined with thymosin , n=75） and control group （budesonide aerosol, n=75） from January 2011 to September 2012.Two groups were compared in the efficacy , the frequency of asthma attack , attack duration , extend of attack , the day symptoms and night symptoms during the asthma persistent period , and the mutation rate of peak expiratory flow （ PEF） .Results The curative efficacy of the observation group was significantly higher than that of the control group （χ^2 =14.52,P〈0.05）.The frequency of asthma attack was lower and the attack duration was shorter in the observation group than the control group （t value was -5.75 and -7.63, respectively, both P〈0.05）.The extend of attack in the observation group was milder than that in control group （Mann-Whitney u=52.5,P〈0.05）.The day symptoms and night symptoms were milder than and the mutation rate of PEF during the asthma persistent period was superior to the control group （P〈0.05）.Conclusion Thymosin combined with budesonide aerosol is better than budesonide aerosol in the treatment of bronchial asthma in children .It should be widely applied .