卵巢功能衰退185例患者就诊症状分析

Symptoms analysis of 185 cases with ovarian failure

目的对不同年龄段卵巢功能衰退患者的就诊症状及相关因素进行分析,以更好指导临床工作。方法选取2011年7月至2012年8月就诊于山西医科大学第一医院妇产科门诊,诊断为卵巢功能衰退患者共185例,其中卵巢早衰32例(包括卵巢早衰6例,过渡期卵巢衰竭26例),围绝经期42例,绝经后111例。对患者的一般状况及就诊症状问诊并行绝经症状评分,整理数据资料进行组间比较及影响因素的统计学分析。结果就诊症状卵巢早衰组月经紊乱占第1位(81.3%);围绝经期组与绝经后组潮热出汗占第1位(71.4%、55.9%);组间比较,月经紊乱、潮热出汗、失眠、骨关节肌肉痛、心悸差异有统计学意义(x^2值分别为108.130、33.697、11.079、17.600、9.871,均P<0.05)。绝经症状与年龄、文化程度有相关性(相关系数分别为0.420、0.549,均P<0.05)。结论主要就诊症状卵巢早衰组为月经紊乱,围绝经期及绝经后组为潮热出汗;绝经后组骨关节肌肉痛发生率高于围绝经期,而卵巢早衰组无此症状;绝经症状随年龄增加而加重,文化程度越低绝经症状越重。

Objective To analyze the symptoms and related factors of ovarian failure in patients with different ages for better guidance for clinical work.Methods From July 2011 to August 2012 185 cases were diagnosed with ovarian failure in outpatient department of gynecology and obstetrics in First Clinical Medical College of Shanxi Medical University , including 32 cases of premature ovarian failure （POF） [6 cases of POF and 26 cases of transitional ovarian failure （TOF）], 42 perimenopausal women and 111 postmenopausal cases. The patients＇ general situations and treatment symptoms were inquired and menopausal symptoms were graded .The data were collected for comparison among groups and statistical analysis of the influencing factors .Results In POF group the treatment symptoms of menstrual disorders ranked first （81.3%）, while in perimenopausal and postmenopausal groups , hot flushes and sweating ranked first （71.4%, 55.9%）.Comparison among groups showed that there were statistically significant differences in menstrual disorders , hot flushes and sweating, insomnia, bone, joint and muscle pain, and heart palpitations （χ2 values was 108.130, 33.697, 11.079, 17.600 and 9.871, respectively, all P〈0.05）.Menopausal symptoms were associated with age and education level （coefficient correlation was 0.420 and 0.549, respectively, both P〈0.05）.Conclusion The main treatment symptoms of the group of POF is menstrual disorders , and hot flushes and sweating are the main treatment symptoms of perimenopausal group and postmenopausal group .The incidence of bone , joint and muscle pain is higher in postmenopausal group than perimenopausal group , but it is not found in the group of POF .Menopausal symptoms increase with age , and the lower education level , the severer menopausal symptoms .