补锌治疗对有感染性疾病婴儿的辅助疗效分析

目的探讨对感染性疾病补锌辅助治疗的疗效。方法收集1～12个月龄大的可能患有严重细菌感染的婴儿，随机分为两个组，补锌组87例和对照组80例，两组除标准的抗菌治疗外，补锌组每天接受口服硫酸锌2mg／（kg·d），对照组接受同等剂量安慰剂，比较两组最终住院时间及严重症状缓解时间。结果两组间性别、月龄、疾病种类、疾病基础状态、高敏C反应蛋白水平、血锌水平比较无显著差异，P〉0．05；补锌组治疗失败7例（8o％），对照组15例（187％），有统计学差异，P〈0.05，补锌治疗降低了治疗失败的相对风险；补锌组住院时间10d，对照组11d，差异无统计学意义，P〉0.05；补锌组症状缓解时间3d，对照组4d，差异有统计学意义，P〈0.05。结论补锌治疗可降低抗感染失败的风险，可以加快严重感染症状的缓解。

Objective To explore the efficacy of the auxiliary treatment of zinc supplementation to infectious disease. Methods We enrolled infants aged 1-12 months with probable serious bacterial infection, from July 2011 to May 2013.They were randomly divided into two groups, to receive either zinc sulfate 2 mg/（kg.d） or placebo in addition to the standard antibiotic treatment. Outcome is length of hospital stay and duration of severe symptoms. Results 87 infants were randomly assigned to receive zinc and 80 to placebo. There is no significant difference between sex, age, disease types, basic status, high-sensitivity c-reactive protein levels and blood zinc levels, P 〉 0.05; There is lower percent of treatment failures occurred in the zinc group [7（8.0%）] than in the placebo group [15（18.7%）], P〈 0.05.zinc reduce the risk of treatment failure; Zinc group were in hospital for 10 days, but the placebo group for 11 days. There are no statistical significance, P 〉 0.05; Zinc group of duration of severe symptoms was 3 days, and the placebo group was 4 days. There was statistically significant, P 〈 0.05. Conclusion Zinc could be given as adjunct treatment to reduce the risk of treatment failure and may speed up attenuation of severe symptoms in infants with probable serious bacterial infection.